This study investigates the clinical, laboratory, and imaging findings of 2019 Novel Coronavirus (2019-nCoV) pneumonia in humans. Fifty-one patients with laboratory-confirmed 2019-nCoV infection were evaluated using thin-section CT. The most common symptoms were fever (96%) and cough (47%). Most patients had normal or decreased white blood cell and neutrophil counts, and reduced lymphocyte counts. Chest CT images showed pure ground-glass opacity (GGO) in 77% of patients, GGO with interstitial and/or interlobular septal thickening in 75%, and GGO with consolidation in 59%. GGOs were bilateral in 88% of patients, involving the posterior lungs in 82% and the peripheral lungs in 85%. Consolidation was more prevalent in patients with a longer interval between symptom onset and CT scan (61% vs. 21%, P < .001) and in older patients (45% vs. 23%, P < .001). Follow-up CT in 13 patients showed improvement in seven (54%) and progression in four (31%). The study concludes that fever and/or cough, bilateral GGOs in the peripheral and posterior lungs, and a history of exposure to individuals from Wuhan, China, are characteristic features of 2019-nCoV pneumonia.This study investigates the clinical, laboratory, and imaging findings of 2019 Novel Coronavirus (2019-nCoV) pneumonia in humans. Fifty-one patients with laboratory-confirmed 2019-nCoV infection were evaluated using thin-section CT. The most common symptoms were fever (96%) and cough (47%). Most patients had normal or decreased white blood cell and neutrophil counts, and reduced lymphocyte counts. Chest CT images showed pure ground-glass opacity (GGO) in 77% of patients, GGO with interstitial and/or interlobular septal thickening in 75%, and GGO with consolidation in 59%. GGOs were bilateral in 88% of patients, involving the posterior lungs in 82% and the peripheral lungs in 85%. Consolidation was more prevalent in patients with a longer interval between symptom onset and CT scan (61% vs. 21%, P < .001) and in older patients (45% vs. 23%, P < .001). Follow-up CT in 13 patients showed improvement in seven (54%) and progression in four (31%). The study concludes that fever and/or cough, bilateral GGOs in the peripheral and posterior lungs, and a history of exposure to individuals from Wuhan, China, are characteristic features of 2019-nCoV pneumonia.