This review highlights the growing problem of emerging antifungal resistance in fungal pathogens, which poses a significant public health threat. The authors discuss the increasing number of fungal outbreaks affecting humans, plants, and animals, and the development of resistance in both previously susceptible and newly emerging fungal species. Key examples include *Aspergillus fumigatus*, which has evolved azole resistance, and *Candida auris*, which has emerged as a highly resistant nosocomial infection. The review also examines the environmental and agricultural factors contributing to the spread of drug-resistant fungal pathogens, such as the use of fungicides and over-the-counter antifungal medications. The authors emphasize the need for a One Health approach, involving collaboration between human, veterinary, agricultural, and environmental sectors, to address this global challenge. They call for improved antimicrobial stewardship and the development of new technologies, such as rapid sequencing, to track and manage the emergence and spread of drug-resistant fungal pathogens.This review highlights the growing problem of emerging antifungal resistance in fungal pathogens, which poses a significant public health threat. The authors discuss the increasing number of fungal outbreaks affecting humans, plants, and animals, and the development of resistance in both previously susceptible and newly emerging fungal species. Key examples include *Aspergillus fumigatus*, which has evolved azole resistance, and *Candida auris*, which has emerged as a highly resistant nosocomial infection. The review also examines the environmental and agricultural factors contributing to the spread of drug-resistant fungal pathogens, such as the use of fungicides and over-the-counter antifungal medications. The authors emphasize the need for a One Health approach, involving collaboration between human, veterinary, agricultural, and environmental sectors, to address this global challenge. They call for improved antimicrobial stewardship and the development of new technologies, such as rapid sequencing, to track and manage the emergence and spread of drug-resistant fungal pathogens.