Poly(lactic acid) (PLA) is widely used in medicine due to its biocompatibility, versatility, and cost-effectiveness. Three-dimensional (3D) printing has enabled the fabrication of customized scaffolds for various biomedical and clinical applications. In tissue engineering and regenerative medicine, 3D-printed PLA is primarily used to generate bone tissue scaffolds, often in combination with other polymers and ceramics. PLA's versatility also allows for the development of drug-eluting constructs for controlled release of various agents, such as antibiotics, antivirals, anti-hypertensives, chemotherapeutics, hormones, and vitamins. Additionally, 3D-printed PLA has been used to develop diagnostic electrodes, prostheses, orthoses, surgical instruments, and radiotherapy devices. It has provided a cost-effective, accessible, and safer means of improving patient care through surgical and dosimetry guides, as well as enhancing medical education through training models and simulators. Overall, the widespread use of 3D-printed PLA in biomedical and clinical settings is expected to stimulate biomedical innovation and revolutionize patient care and healthcare delivery.Poly(lactic acid) (PLA) is widely used in medicine due to its biocompatibility, versatility, and cost-effectiveness. Three-dimensional (3D) printing has enabled the fabrication of customized scaffolds for various biomedical and clinical applications. In tissue engineering and regenerative medicine, 3D-printed PLA is primarily used to generate bone tissue scaffolds, often in combination with other polymers and ceramics. PLA's versatility also allows for the development of drug-eluting constructs for controlled release of various agents, such as antibiotics, antivirals, anti-hypertensives, chemotherapeutics, hormones, and vitamins. Additionally, 3D-printed PLA has been used to develop diagnostic electrodes, prostheses, orthoses, surgical instruments, and radiotherapy devices. It has provided a cost-effective, accessible, and safer means of improving patient care through surgical and dosimetry guides, as well as enhancing medical education through training models and simulators. Overall, the widespread use of 3D-printed PLA in biomedical and clinical settings is expected to stimulate biomedical innovation and revolutionize patient care and healthcare delivery.