Poly(lactic acid) (PLA) is widely used in medicine due to its biocompatibility, versatility, and cost-effectiveness. Three-dimensional (3D) printing has enabled the fabrication of customized scaffolds for various biomedical and clinical applications. 3D-printed PLA is used in tissue engineering and regenerative medicine to generate bone tissue scaffolds, often combined with other materials. It has also been used to develop drug-eluting constructs for controlled release of various agents. Additionally, 3D-printed PLA has been used to develop diagnostic electrodes, prostheses, orthoses, surgical instruments, and radiotherapy devices. PLA provides a cost-effective and safe means of improving patient care through surgical and dosimetry guides, as well as enhancing medical education through training models and simulators. The widespread use of 3D-printed PLA in biomedical and clinical settings is expected to continue stimulating biomedical innovation and revolutionize patient care and healthcare delivery. PLA's versatility allows it to be used in various applications, including bone tissue engineering, drug delivery systems, medical devices, surgical instruments and guides, radiotherapy devices and phantoms, and training models. 3D printing of PLA has enabled the fabrication of intricate scaffold geometries that can be customized for various biomedical and clinical purposes. PLA-based materials are used in tissue engineering and regenerative medicine, drug delivery systems, medical devices, surgical instruments and guides, radiotherapy devices and phantoms, and training models. PLA's degradation in the body and its biocompatibility make it suitable for medical devices that can safely interface with human tissues and organs. PLA's affordability, combined with its versatility and biocompatibility, makes it an ideal candidate for the fabrication of novel medical devices and delivery systems through 3D printing. The review focuses on the wide range of biomedical and clinical applications of 3D-printed PLA, highlighting its transformative potential in patient care and healthcare delivery. 3D-printed PLA has been used in bone tissue engineering, nerve, skin, and vascular tissue regeneration, and in the development of medical devices, prosthetics, and orthotics. It has also been used in surgical instruments and guides, radiotherapy devices and phantoms, and training models and simulators. The review discusses the potential of 3D-printed PLA in various applications, including drug delivery, tissue engineering, and medical devices. The review also highlights the challenges and future directions for the application of 3D-printed PLA in medicine.Poly(lactic acid) (PLA) is widely used in medicine due to its biocompatibility, versatility, and cost-effectiveness. Three-dimensional (3D) printing has enabled the fabrication of customized scaffolds for various biomedical and clinical applications. 3D-printed PLA is used in tissue engineering and regenerative medicine to generate bone tissue scaffolds, often combined with other materials. It has also been used to develop drug-eluting constructs for controlled release of various agents. Additionally, 3D-printed PLA has been used to develop diagnostic electrodes, prostheses, orthoses, surgical instruments, and radiotherapy devices. PLA provides a cost-effective and safe means of improving patient care through surgical and dosimetry guides, as well as enhancing medical education through training models and simulators. The widespread use of 3D-printed PLA in biomedical and clinical settings is expected to continue stimulating biomedical innovation and revolutionize patient care and healthcare delivery. PLA's versatility allows it to be used in various applications, including bone tissue engineering, drug delivery systems, medical devices, surgical instruments and guides, radiotherapy devices and phantoms, and training models. 3D printing of PLA has enabled the fabrication of intricate scaffold geometries that can be customized for various biomedical and clinical purposes. PLA-based materials are used in tissue engineering and regenerative medicine, drug delivery systems, medical devices, surgical instruments and guides, radiotherapy devices and phantoms, and training models. PLA's degradation in the body and its biocompatibility make it suitable for medical devices that can safely interface with human tissues and organs. PLA's affordability, combined with its versatility and biocompatibility, makes it an ideal candidate for the fabrication of novel medical devices and delivery systems through 3D printing. The review focuses on the wide range of biomedical and clinical applications of 3D-printed PLA, highlighting its transformative potential in patient care and healthcare delivery. 3D-printed PLA has been used in bone tissue engineering, nerve, skin, and vascular tissue regeneration, and in the development of medical devices, prosthetics, and orthotics. It has also been used in surgical instruments and guides, radiotherapy devices and phantoms, and training models and simulators. The review discusses the potential of 3D-printed PLA in various applications, including drug delivery, tissue engineering, and medical devices. The review also highlights the challenges and future directions for the application of 3D-printed PLA in medicine.