This review article explores the emerging trends and potential applications of bilosomes as therapeutic drug delivery systems. Bilosomes, derived from bile acids, are modified liposomes or niosomes that enhance stability, absorption, and permeation in the gastrointestinal (GI) tract. They are particularly useful for delivering lipophilic and poorly permeable drugs, improving their bioavailability and therapeutic efficacy. The article discusses the structural aspects of bilosomes, including the use of bile salts, non-ionic surfactants, and lipids, which contribute to their enhanced properties. Additionally, it highlights the therapeutic applications of bilosomes in various disease areas, such as brain disorders, ocular diseases, oral vaccines, protein/peptide delivery, and cancer treatment. Studies demonstrate that bilosomes can improve drug delivery through the blood-brain barrier, enhance ocular drug residence time, stimulate immune responses for oral vaccines, and increase the bioavailability of proteins and peptides. They also show promise in transdermal drug delivery, overcoming skin barriers and improving drug permeation. Overall, bilosomes offer a promising nanocarrier system for enhancing the efficacy of various drugs and addressing the challenges associated with traditional delivery methods.This review article explores the emerging trends and potential applications of bilosomes as therapeutic drug delivery systems. Bilosomes, derived from bile acids, are modified liposomes or niosomes that enhance stability, absorption, and permeation in the gastrointestinal (GI) tract. They are particularly useful for delivering lipophilic and poorly permeable drugs, improving their bioavailability and therapeutic efficacy. The article discusses the structural aspects of bilosomes, including the use of bile salts, non-ionic surfactants, and lipids, which contribute to their enhanced properties. Additionally, it highlights the therapeutic applications of bilosomes in various disease areas, such as brain disorders, ocular diseases, oral vaccines, protein/peptide delivery, and cancer treatment. Studies demonstrate that bilosomes can improve drug delivery through the blood-brain barrier, enhance ocular drug residence time, stimulate immune responses for oral vaccines, and increase the bioavailability of proteins and peptides. They also show promise in transdermal drug delivery, overcoming skin barriers and improving drug permeation. Overall, bilosomes offer a promising nanocarrier system for enhancing the efficacy of various drugs and addressing the challenges associated with traditional delivery methods.