The article discusses the increasing threat of fungal diseases to animal, plant, and ecosystem health. It highlights recent examples of severe die-offs and extinctions in wild species caused by fungal infections, such as white nose syndrome in bats and chytridiomycosis in amphibians. The authors argue that human activities, including trade and transportation, are intensifying fungal disease dispersal and creating new opportunities for evolution. They emphasize the need for tighter biosecurity measures and increased monitoring to prevent the further emergence of fungal diseases and their impact on biodiversity and ecosystem services. The article also explores the dynamics of fungal disease emergence, including the role of high virulence, long-lived environmental stages, and the impact of climate change. It concludes by calling for integrated approaches that combine epidemiological studies with environmental change research to better understand and manage fungal diseases.The article discusses the increasing threat of fungal diseases to animal, plant, and ecosystem health. It highlights recent examples of severe die-offs and extinctions in wild species caused by fungal infections, such as white nose syndrome in bats and chytridiomycosis in amphibians. The authors argue that human activities, including trade and transportation, are intensifying fungal disease dispersal and creating new opportunities for evolution. They emphasize the need for tighter biosecurity measures and increased monitoring to prevent the further emergence of fungal diseases and their impact on biodiversity and ecosystem services. The article also explores the dynamics of fungal disease emergence, including the role of high virulence, long-lived environmental stages, and the impact of climate change. It concludes by calling for integrated approaches that combine epidemiological studies with environmental change research to better understand and manage fungal diseases.