RNA modifications, particularly N6-methyladenosine (m6A), 5-methylcytosine (m5C), and N7-methylguanosine (m7G), play critical roles in cancer progression through various mechanisms. Long noncoding RNAs (lncRNAs) are involved in cancer development and progression by regulating gene expression, epigenetic modifications, and signaling pathways. These modifications influence lncRNA stability, structure, and function, which in turn affect cancer cell behavior. m6A, m5C, and m7G modifications are key epigenetic regulators that modulate lncRNA activity, impacting cancer progression. This review summarizes the roles of these modifications in lncRNAs and their interactions in various cancers, highlighting their potential as therapeutic targets and biomarkers. The study emphasizes the importance of understanding the mechanisms of RNA modifications in lncRNAs for developing new cancer therapies and improving diagnosis. The review also discusses the current research on m6A, m5C, and m7G modifications in different cancers, including lung, liver, gastric, pancreatic, breast, head and neck, and other cancers. The findings suggest that targeting these modifications could provide new insights into cancer treatment and prognosis.RNA modifications, particularly N6-methyladenosine (m6A), 5-methylcytosine (m5C), and N7-methylguanosine (m7G), play critical roles in cancer progression through various mechanisms. Long noncoding RNAs (lncRNAs) are involved in cancer development and progression by regulating gene expression, epigenetic modifications, and signaling pathways. These modifications influence lncRNA stability, structure, and function, which in turn affect cancer cell behavior. m6A, m5C, and m7G modifications are key epigenetic regulators that modulate lncRNA activity, impacting cancer progression. This review summarizes the roles of these modifications in lncRNAs and their interactions in various cancers, highlighting their potential as therapeutic targets and biomarkers. The study emphasizes the importance of understanding the mechanisms of RNA modifications in lncRNAs for developing new cancer therapies and improving diagnosis. The review also discusses the current research on m6A, m5C, and m7G modifications in different cancers, including lung, liver, gastric, pancreatic, breast, head and neck, and other cancers. The findings suggest that targeting these modifications could provide new insights into cancer treatment and prognosis.