This review article explores the emerging role of RNA modifications, particularly N6-methyladenosine (m6A), 5-methylcytosine (m5C), and N7-methylguanosine (m7G) methylation, in cancer. It highlights the significance of long noncoding RNAs (lncRNAs) in cancer progression and their interaction with RNA modifications. The article discusses how these modifications affect lncRNA structure, stability, and function, influencing various biological processes such as gene transcription, splicing, and protein activity. It also reviews the mechanisms by which RNA modifications regulate lncRNAs, including the involvement of "writers," "erasers," and "readers" enzymes. The review further examines the impact of m6A, m5C, and m7G modifications on different types of cancer, including lung, liver, gastric, pancreatic, colorectal, breast, head and neck, and other cancers. It emphasizes the potential of targeting RNA modifications and lncRNAs as therapeutic strategies in cancer treatment. The article concludes by highlighting the need for further research to elucidate the complex regulatory networks of RNA modifications in cancer and to develop targeted therapies based on these findings.This review article explores the emerging role of RNA modifications, particularly N6-methyladenosine (m6A), 5-methylcytosine (m5C), and N7-methylguanosine (m7G) methylation, in cancer. It highlights the significance of long noncoding RNAs (lncRNAs) in cancer progression and their interaction with RNA modifications. The article discusses how these modifications affect lncRNA structure, stability, and function, influencing various biological processes such as gene transcription, splicing, and protein activity. It also reviews the mechanisms by which RNA modifications regulate lncRNAs, including the involvement of "writers," "erasers," and "readers" enzymes. The review further examines the impact of m6A, m5C, and m7G modifications on different types of cancer, including lung, liver, gastric, pancreatic, colorectal, breast, head and neck, and other cancers. It emphasizes the potential of targeting RNA modifications and lncRNAs as therapeutic strategies in cancer treatment. The article concludes by highlighting the need for further research to elucidate the complex regulatory networks of RNA modifications in cancer and to develop targeted therapies based on these findings.