The article by Jansen, van den Berg, and Meijer (1994) reports the encapsulation of guest molecules into a dendritic box, a highly branched macromolecule. The authors synthesized dendritic boxes by constructing a chiral shell of protected amino acids onto poly(propyleneimine) dendrimers with 64 amine end groups. Nuclear magnetic resonance (NMR) and optical data confirmed the formation of a dense, solid-phase character in the shell. Guest molecules were captured within the internal cavities of the boxes, and their diffusion out of the boxes into solution was found to be unmeasurably slow due to the close packing of the shell. The monomolecular dendritic containers, with dimensions of 5 nanometers, were characterized spectroscopically. The study demonstrated the potential of these dendritic boxes as physical containers for guest molecules, with applications in areas such as fluorescent markers and controlled delivery.The article by Jansen, van den Berg, and Meijer (1994) reports the encapsulation of guest molecules into a dendritic box, a highly branched macromolecule. The authors synthesized dendritic boxes by constructing a chiral shell of protected amino acids onto poly(propyleneimine) dendrimers with 64 amine end groups. Nuclear magnetic resonance (NMR) and optical data confirmed the formation of a dense, solid-phase character in the shell. Guest molecules were captured within the internal cavities of the boxes, and their diffusion out of the boxes into solution was found to be unmeasurably slow due to the close packing of the shell. The monomolecular dendritic containers, with dimensions of 5 nanometers, were characterized spectroscopically. The study demonstrated the potential of these dendritic boxes as physical containers for guest molecules, with applications in areas such as fluorescent markers and controlled delivery.