Endocrine-disrupting chemicals (EDCs) are a significant concern for public health, as they can interfere with the body's endocrine system, leading to adverse developmental, reproductive, neurological, cardiovascular, metabolic, and immune effects. EDCs are found in various everyday products, including plastics, food cans, detergents, and pesticides. They can alter hormone levels, inhibit or stimulate hormone production, and affect hormone transport, causing a wide range of health issues. The review focuses on the mechanisms by which EDCs alter hormone signaling, including their interaction with nuclear hormone receptors and other non-steroid receptors. It also highlights the importance of low-dose effects, developmental windows of susceptibility, and transgenerational actions of EDCs. The article discusses specific disease endpoints associated with endocrine disruption, such as male and female reproductive disorders, obesity, and metabolic disorders. The authors emphasize the need for further research to identify and classify the diseases caused by EDCs and to develop effective prevention strategies.Endocrine-disrupting chemicals (EDCs) are a significant concern for public health, as they can interfere with the body's endocrine system, leading to adverse developmental, reproductive, neurological, cardiovascular, metabolic, and immune effects. EDCs are found in various everyday products, including plastics, food cans, detergents, and pesticides. They can alter hormone levels, inhibit or stimulate hormone production, and affect hormone transport, causing a wide range of health issues. The review focuses on the mechanisms by which EDCs alter hormone signaling, including their interaction with nuclear hormone receptors and other non-steroid receptors. It also highlights the importance of low-dose effects, developmental windows of susceptibility, and transgenerational actions of EDCs. The article discusses specific disease endpoints associated with endocrine disruption, such as male and female reproductive disorders, obesity, and metabolic disorders. The authors emphasize the need for further research to identify and classify the diseases caused by EDCs and to develop effective prevention strategies.