The Endocrine Society has developed clinical practice guidelines for the endocrine treatment of transsexual individuals. The guidelines aim to provide a safe and effective hormone regimen that suppresses endogenous hormone secretion and maintains sex hormone levels within the normal range for the desired gender. Mental health professionals (MHPs) must recommend and participate in ongoing care, while endocrinologists confirm the diagnostic criteria used by MHPs. The guidelines recommend against endocrine treatment for prepubertal children due to the high rate of remission after puberty. For adolescents, pubertal suppression with GnRH analogs is recommended until age 16, after which cross-sex hormones can be administered. Adult transsexual individuals should be informed about fertility options before starting hormone treatment. The guidelines also emphasize the importance of multidisciplinary collaboration and thorough diagnostic assessments to ensure safe and effective treatment.The Endocrine Society has developed clinical practice guidelines for the endocrine treatment of transsexual individuals. The guidelines aim to provide a safe and effective hormone regimen that suppresses endogenous hormone secretion and maintains sex hormone levels within the normal range for the desired gender. Mental health professionals (MHPs) must recommend and participate in ongoing care, while endocrinologists confirm the diagnostic criteria used by MHPs. The guidelines recommend against endocrine treatment for prepubertal children due to the high rate of remission after puberty. For adolescents, pubertal suppression with GnRH analogs is recommended until age 16, after which cross-sex hormones can be administered. Adult transsexual individuals should be informed about fertility options before starting hormone treatment. The guidelines also emphasize the importance of multidisciplinary collaboration and thorough diagnostic assessments to ensure safe and effective treatment.