Endothelial Dysfunction

Endothelial Dysfunction

2003;108:2060-2061 | James T. Willerson, MD; Dean J. Kereiakes, MD
The article discusses the importance of endothelial dysfunction in the development of atherothrombosis and vascular disease. Drs. Ganz, Vita, Verma, Buchanan, and Anderson present evidence that endothelial function is dynamically regulated and can be significantly impaired by various injuries such as atherosclerosis, hypertension, diabetes, inflammation, and aging. They highlight that endothelial dysfunction precedes the clinical consequences of atherothrombosis and suggests that testing methods should evaluate more aspects of endothelial function, including antithrombotic, metabolic, and anti-inflammatory properties. The authors also discuss the need for improved noninvasive imaging techniques to assess endothelial function in different arteries and the development of biomarkers that can specifically detect early and progressive endothelial dysfunction. While current studies do not provide compelling evidence that biomarkers like C-reactive protein specifically correlate with endothelial dysfunction, future research may offer more insights. The article emphasizes the potential of endothelial functional testing in predicting and managing vascular disease through early intervention.The article discusses the importance of endothelial dysfunction in the development of atherothrombosis and vascular disease. Drs. Ganz, Vita, Verma, Buchanan, and Anderson present evidence that endothelial function is dynamically regulated and can be significantly impaired by various injuries such as atherosclerosis, hypertension, diabetes, inflammation, and aging. They highlight that endothelial dysfunction precedes the clinical consequences of atherothrombosis and suggests that testing methods should evaluate more aspects of endothelial function, including antithrombotic, metabolic, and anti-inflammatory properties. The authors also discuss the need for improved noninvasive imaging techniques to assess endothelial function in different arteries and the development of biomarkers that can specifically detect early and progressive endothelial dysfunction. While current studies do not provide compelling evidence that biomarkers like C-reactive protein specifically correlate with endothelial dysfunction, future research may offer more insights. The article emphasizes the potential of endothelial functional testing in predicting and managing vascular disease through early intervention.
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