The article discusses the use of nanotopography to control cell function and tissue engineering. It reviews how nanoscale topography influences cell behavior, including cell morphology, adhesion, proliferation, and migration. The study highlights the potential of nanotopography to direct stem cell differentiation and tissue organization. It also explores the mechanisms behind cell-nanotopography interactions, such as the role of filopodia, focal adhesions, and actin polymerization. The article discusses the fabrication of synthetic nanotopographic substrates and their application in tissue engineering, including the use of materials like PDMS and polymers. It also addresses the challenges and opportunities in cell-nanotopography engineering, including the need for further research into the underlying mechanisms and the development of new materials and fabrication techniques. The study concludes that nanotopography has significant potential in controlling cell function and tissue engineering, and that further research is needed to fully understand and utilize its capabilities.The article discusses the use of nanotopography to control cell function and tissue engineering. It reviews how nanoscale topography influences cell behavior, including cell morphology, adhesion, proliferation, and migration. The study highlights the potential of nanotopography to direct stem cell differentiation and tissue organization. It also explores the mechanisms behind cell-nanotopography interactions, such as the role of filopodia, focal adhesions, and actin polymerization. The article discusses the fabrication of synthetic nanotopographic substrates and their application in tissue engineering, including the use of materials like PDMS and polymers. It also addresses the challenges and opportunities in cell-nanotopography engineering, including the need for further research into the underlying mechanisms and the development of new materials and fabrication techniques. The study concludes that nanotopography has significant potential in controlling cell function and tissue engineering, and that further research is needed to fully understand and utilize its capabilities.