Enhancing diabetic wound healing: advances in electrospun scaffolds from pathogenesis to therapeutic applications

Enhancing diabetic wound healing: advances in electrospun scaffolds from pathogenesis to therapeutic applications

05 February 2024 | Xuewen Jiang, Yu-E Zeng, Chaofei Li, Ke Wang, Deng-Guang Yu
Diabetic wounds, characterized by elevated levels of inflammatory cytokines, MMPs, and ROS, pose significant challenges in wound healing due to impaired angiogenesis, persistent infections, and high hospitalization rates. Electrospun scaffolds, which mimic the extracellular matrix (ECM) and exhibit adjustable composition and size, are promising for diabetic wound treatment. These scaffolds facilitate cell adhesion, growth, and migration, promote new skin tissue formation, and support drug delivery through controlled release. The porous nature of these scaffolds enhances gas exchange and exudate absorption, while surface modifications can impart specific functionalities. This article reviews the pathological mechanisms of diabetic wounds, including diabetic foot ulcers (DFUs), and explores the advantages of electrospun nanofiber scaffolds in wound healing. It also summarizes studies on various nanofiber scaffold structures and drug loading methods, highlighting their potential in treating diabetic wounds. Electrospinning technology allows for precise control over fiber structure, making it a versatile tool in biomedical applications, including wound dressing, drug delivery, and tissue engineering. The article concludes by discussing the application of electrospun scaffolds in diabetic wound healing, emphasizing their role in promoting wound closure, angiogenesis, and reducing inflammation.Diabetic wounds, characterized by elevated levels of inflammatory cytokines, MMPs, and ROS, pose significant challenges in wound healing due to impaired angiogenesis, persistent infections, and high hospitalization rates. Electrospun scaffolds, which mimic the extracellular matrix (ECM) and exhibit adjustable composition and size, are promising for diabetic wound treatment. These scaffolds facilitate cell adhesion, growth, and migration, promote new skin tissue formation, and support drug delivery through controlled release. The porous nature of these scaffolds enhances gas exchange and exudate absorption, while surface modifications can impart specific functionalities. This article reviews the pathological mechanisms of diabetic wounds, including diabetic foot ulcers (DFUs), and explores the advantages of electrospun nanofiber scaffolds in wound healing. It also summarizes studies on various nanofiber scaffold structures and drug loading methods, highlighting their potential in treating diabetic wounds. Electrospinning technology allows for precise control over fiber structure, making it a versatile tool in biomedical applications, including wound dressing, drug delivery, and tissue engineering. The article concludes by discussing the application of electrospun scaffolds in diabetic wound healing, emphasizing their role in promoting wound closure, angiogenesis, and reducing inflammation.
Reach us at info@study.space