This review focuses on the impact of endocrine-disrupting chemicals (EDCs) on the development of metabolic dysfunction-associated steatotic liver disease (MASLD) in children, independent of their obesogenic effects. EDCs, including various plastics, pesticides, and metals, can accumulate in the liver, exacerbating inflammation and contributing to insulin resistance, which is crucial in the pathogenesis of MASLD. The liver plays a pivotal role in metabolic and detoxification processes, and EDCs can disrupt these processes by altering hormone levels and transport, leading to chronic low-grade inflammation. Studies have shown that exposure to EDCs during fetal and early childhood stages can impact the epigenome, causing alterations in DNA methylation and histone modifications, which influence hepatometabolic reprogramming. The review highlights the importance of addressing environmental factors in the prevention and treatment of MASLD, emphasizing the need for public health policies to mitigate chemical exposure during critical developmental stages. Future research should focus on identifying exposed individuals and developing clinical markers to facilitate the monitoring and early intervention of MASLD.This review focuses on the impact of endocrine-disrupting chemicals (EDCs) on the development of metabolic dysfunction-associated steatotic liver disease (MASLD) in children, independent of their obesogenic effects. EDCs, including various plastics, pesticides, and metals, can accumulate in the liver, exacerbating inflammation and contributing to insulin resistance, which is crucial in the pathogenesis of MASLD. The liver plays a pivotal role in metabolic and detoxification processes, and EDCs can disrupt these processes by altering hormone levels and transport, leading to chronic low-grade inflammation. Studies have shown that exposure to EDCs during fetal and early childhood stages can impact the epigenome, causing alterations in DNA methylation and histone modifications, which influence hepatometabolic reprogramming. The review highlights the importance of addressing environmental factors in the prevention and treatment of MASLD, emphasizing the need for public health policies to mitigate chemical exposure during critical developmental stages. Future research should focus on identifying exposed individuals and developing clinical markers to facilitate the monitoring and early intervention of MASLD.