The study found that lipomatous change in thyroid nodules can occur in two pathways: focal lipidization of tumor cells in oncocytic-type follicular adenomas and intratumoral fat in stromal cells of adenomatous nodules. The increased incidence of lipomatous change in oncocytic neoplasms and adenomatous nodules in multinodular hyperplasia suggests altered metabolic activity. Additional studies are needed to establish the molecular basis for these observations. Galectin-3 (Gal-3) was highly expressed in functioning corticotrop adenomas but not in silent ones, suggesting that Gal-3 may serve as a useful marker for distinguishing silent corticotrop adenomas of the pituitary gland. The Pheochromocytoma Adrenal Scaler Score (PASS) system was validated in a retrospective review of adrenal pheochromocytomas and extra-adrenal paragangliomas. The PASS scores correlated poorly with MIB-1 staining intensity, indicating a high false-positive rate and low positive predictive value. More discriminative parameters, including genetic-molecular markers, are needed for optimal stratification. Chronic long-term, low-dose ionizing radiation exposure leads to alterations in cell cycle regulatory molecules, such as p53, mdm2, p21WAF1/CIP1, p16INK4a, and p14ARF, which may contribute to enhanced tumor progression and aggressivity. Cancer is emerging as a major public health problem in north central Nigeria, competing with infectious diseases. Between 1985 and 2004, 5066 cancers were diagnosed, representing 14.6% of all diagnosed specimens. Environmental exposure to toxic elements like aluminum, lead, mercury, and cadmium is common in the population of Ceara, Brazil. The study found that these elements are present in scalp hair samples, indicating potential health risks. Autopsy cases of Minamata disease in Japan showed four types of pathological changes: acute adult, chronic adult, infantile, and fetal. Mercury poisoning caused severe damage to the central nervous system and peripheral sensory nerves, with regeneration observed in the peripheral nerves over time. Hypoxic newborn piglets resuscitated with 100% oxygen showed the most cardiac reoxygenation-induced injury, with marked architectural disruption and myocardial necrosis. The degree of injury was not significantly different between 18% and 21% oxygen groups. The Ontario Tumour Bank (OTB) has successfully collected tissue samples, blood, and clinical information from 406 donors, with gynecological, lung, and breast cancers being the most common. The OTB provides a valuable resource for translational research. Long-term rapamycin (RAPA) treatment reduced the spontaneous formation of de novo cancer in p53 knockout mice, while mycophenolate mofThe study found that lipomatous change in thyroid nodules can occur in two pathways: focal lipidization of tumor cells in oncocytic-type follicular adenomas and intratumoral fat in stromal cells of adenomatous nodules. The increased incidence of lipomatous change in oncocytic neoplasms and adenomatous nodules in multinodular hyperplasia suggests altered metabolic activity. Additional studies are needed to establish the molecular basis for these observations. Galectin-3 (Gal-3) was highly expressed in functioning corticotrop adenomas but not in silent ones, suggesting that Gal-3 may serve as a useful marker for distinguishing silent corticotrop adenomas of the pituitary gland. The Pheochromocytoma Adrenal Scaler Score (PASS) system was validated in a retrospective review of adrenal pheochromocytomas and extra-adrenal paragangliomas. The PASS scores correlated poorly with MIB-1 staining intensity, indicating a high false-positive rate and low positive predictive value. More discriminative parameters, including genetic-molecular markers, are needed for optimal stratification. Chronic long-term, low-dose ionizing radiation exposure leads to alterations in cell cycle regulatory molecules, such as p53, mdm2, p21WAF1/CIP1, p16INK4a, and p14ARF, which may contribute to enhanced tumor progression and aggressivity. Cancer is emerging as a major public health problem in north central Nigeria, competing with infectious diseases. Between 1985 and 2004, 5066 cancers were diagnosed, representing 14.6% of all diagnosed specimens. Environmental exposure to toxic elements like aluminum, lead, mercury, and cadmium is common in the population of Ceara, Brazil. The study found that these elements are present in scalp hair samples, indicating potential health risks. Autopsy cases of Minamata disease in Japan showed four types of pathological changes: acute adult, chronic adult, infantile, and fetal. Mercury poisoning caused severe damage to the central nervous system and peripheral sensory nerves, with regeneration observed in the peripheral nerves over time. Hypoxic newborn piglets resuscitated with 100% oxygen showed the most cardiac reoxygenation-induced injury, with marked architectural disruption and myocardial necrosis. The degree of injury was not significantly different between 18% and 21% oxygen groups. The Ontario Tumour Bank (OTB) has successfully collected tissue samples, blood, and clinical information from 406 donors, with gynecological, lung, and breast cancers being the most common. The OTB provides a valuable resource for translational research. Long-term rapamycin (RAPA) treatment reduced the spontaneous formation of de novo cancer in p53 knockout mice, while mycophenolate mof