The article "Environmental Obesogens and Their Perturbations in Lipid Metabolism" by Xiaoyun Wang, Zhendong Sun, Qian S. Liu, Qunfang Zhou, and Guibin Jiang provides a comprehensive review of the impact of environmental obesogens on lipid metabolism. The authors highlight that obesity is a global pandemic, and the disruption of lipid homeostasis by various chemicals is a significant contributing factor. Over 50 chemicals have been identified as environmental obesogens, which can interfere with lipid metabolism through multiple targets, including nuclear receptors, transcription factors, cytokines, and hormones. The review discusses the mechanisms by which these chemicals induce lipid metabolism disorders, such as adipogenesis, energy storage, and appetite regulation. The article also explores the environmental occurrence and human exposure levels of various obesogens, including organotins, per- and polyfluoroalkyl substances (PFASs), phthalates (PAEs), flame retardants, polybrominated diphenyl ethers (PBDEs), and phenols. It details the biological monitoring methods used to measure obesogen levels in human body fluids and tissues, such as breast milk, blood, and urine. Epidemiological studies are discussed, showing correlations between obesogen exposure and metabolic parameters, although the relationship between exposure and disease is often correlative rather than causal. The review further examines the influencing factors that affect the impact of obesogens on lipid metabolism, including transgenerational effects, susceptibility windows, gender differences, structure–effect relationships, and dietary habits. It highlights the importance of understanding these factors to better predict and mitigate the effects of obesogens. Finally, the article outlines various research approaches used to study the obesogenic effects of environmental chemicals, including in vitro and in vivo experiments, epidemiological strategies, and molecular docking. Each method is evaluated for its strengths and limitations, emphasizing the need for a comprehensive understanding of the complex interactions between obesogens and lipid metabolism.The article "Environmental Obesogens and Their Perturbations in Lipid Metabolism" by Xiaoyun Wang, Zhendong Sun, Qian S. Liu, Qunfang Zhou, and Guibin Jiang provides a comprehensive review of the impact of environmental obesogens on lipid metabolism. The authors highlight that obesity is a global pandemic, and the disruption of lipid homeostasis by various chemicals is a significant contributing factor. Over 50 chemicals have been identified as environmental obesogens, which can interfere with lipid metabolism through multiple targets, including nuclear receptors, transcription factors, cytokines, and hormones. The review discusses the mechanisms by which these chemicals induce lipid metabolism disorders, such as adipogenesis, energy storage, and appetite regulation. The article also explores the environmental occurrence and human exposure levels of various obesogens, including organotins, per- and polyfluoroalkyl substances (PFASs), phthalates (PAEs), flame retardants, polybrominated diphenyl ethers (PBDEs), and phenols. It details the biological monitoring methods used to measure obesogen levels in human body fluids and tissues, such as breast milk, blood, and urine. Epidemiological studies are discussed, showing correlations between obesogen exposure and metabolic parameters, although the relationship between exposure and disease is often correlative rather than causal. The review further examines the influencing factors that affect the impact of obesogens on lipid metabolism, including transgenerational effects, susceptibility windows, gender differences, structure–effect relationships, and dietary habits. It highlights the importance of understanding these factors to better predict and mitigate the effects of obesogens. Finally, the article outlines various research approaches used to study the obesogenic effects of environmental chemicals, including in vitro and in vivo experiments, epidemiological strategies, and molecular docking. Each method is evaluated for its strengths and limitations, emphasizing the need for a comprehensive understanding of the complex interactions between obesogens and lipid metabolism.