The article by Alexandre Vallée, MD, PhD, explores the transformative potential of digital twins in personalized medicine. Digital twins are digital replicas of individuals, integrating various health data sources to provide comprehensive insights into patient health, risk assessment, clinical trials, drug development, and patient monitoring. They enable real-time monitoring, predictive modeling, and personalized interventions, enhancing treatment efficacy and patient outcomes. However, the rapid evolution of this technology also raises ethical concerns, such as data privacy, consent, and potential biases. The article emphasizes the need for robust guidelines and regulations to ensure responsible integration of digital twins in healthcare, balancing innovation with ethical responsibility. Despite challenges, the integration of digital twins holds promise for revolutionizing personalized medicine, leading to more tailored and effective treatments.The article by Alexandre Vallée, MD, PhD, explores the transformative potential of digital twins in personalized medicine. Digital twins are digital replicas of individuals, integrating various health data sources to provide comprehensive insights into patient health, risk assessment, clinical trials, drug development, and patient monitoring. They enable real-time monitoring, predictive modeling, and personalized interventions, enhancing treatment efficacy and patient outcomes. However, the rapid evolution of this technology also raises ethical concerns, such as data privacy, consent, and potential biases. The article emphasizes the need for robust guidelines and regulations to ensure responsible integration of digital twins in healthcare, balancing innovation with ethical responsibility. Despite challenges, the integration of digital twins holds promise for revolutionizing personalized medicine, leading to more tailored and effective treatments.