This summary covers the sixth volume of Newton's mathematical papers, focusing on his most productive period, including the Principia. Dr. Whiteside has compiled significant extracts from Newton's manuscripts related to his research on motion and gravity. These include the dynamical theory of motion under central forces and his attempts to explain comet and lunar motions. In 1684, after a challenge from Christopher Wren, Edmund Halley visited Newton, reigniting his interest in the general dynamical theory. Hooke posed a key question about the path of a planet under the Sun's attraction, leading Newton to draft a tract on the motion of bodies in an orbit. This tract, along with an English translation, is included in the volume, showing how the first book of the Principia evolved. The volume also includes manuscripts on various problems, such as the solid of least resistance and the lunar apogee. It concludes with a scheme for revising the Principia. The volume maintains high standards of annotation and printing. The book "Kinetics of Enzyme Mechanisms" by J. T. F. Wong is reviewed. It covers steady-state derivations of rate equations, with rigorous treatments and helpful tips. Some nomenclature is different from usual, and some algebraic shortcuts may make it difficult for the inexperienced. The author's critical judgment is valuable. Dalziel coefficients are used effectively, though Dalziel's treatment is not used as an extended example for three substrate reactions. The book also touches on transient and relaxation kinetics, though not satisfactorily. The lag phase treatment is discussed, though less practical than the analysis of transient enzyme-bound product formation. The examples given for relaxation studies are common in other textbooks. The reviewer recommends the book for graduate students and research workers with basic knowledge of kinetics and calculus.This summary covers the sixth volume of Newton's mathematical papers, focusing on his most productive period, including the Principia. Dr. Whiteside has compiled significant extracts from Newton's manuscripts related to his research on motion and gravity. These include the dynamical theory of motion under central forces and his attempts to explain comet and lunar motions. In 1684, after a challenge from Christopher Wren, Edmund Halley visited Newton, reigniting his interest in the general dynamical theory. Hooke posed a key question about the path of a planet under the Sun's attraction, leading Newton to draft a tract on the motion of bodies in an orbit. This tract, along with an English translation, is included in the volume, showing how the first book of the Principia evolved. The volume also includes manuscripts on various problems, such as the solid of least resistance and the lunar apogee. It concludes with a scheme for revising the Principia. The volume maintains high standards of annotation and printing. The book "Kinetics of Enzyme Mechanisms" by J. T. F. Wong is reviewed. It covers steady-state derivations of rate equations, with rigorous treatments and helpful tips. Some nomenclature is different from usual, and some algebraic shortcuts may make it difficult for the inexperienced. The author's critical judgment is valuable. Dalziel coefficients are used effectively, though Dalziel's treatment is not used as an extended example for three substrate reactions. The book also touches on transient and relaxation kinetics, though not satisfactorily. The lag phase treatment is discussed, though less practical than the analysis of transient enzyme-bound product formation. The examples given for relaxation studies are common in other textbooks. The reviewer recommends the book for graduate students and research workers with basic knowledge of kinetics and calculus.