Eph receptors and ephrins are key players in cancer development and progression, with bidirectional signaling between them influencing tumor growth, invasion, angiogenesis, and metastasis. Eph receptors and ephrins are expressed in cancer cells and tumor blood vessels, and their dysregulation can contribute to cancer pathogenesis. Eph signaling is complex, with both promoting and inhibiting effects on tumorigenicity. Eph receptors and ephrins are promising therapeutic targets in cancer, as they can be modulated to suppress tumor growth and enhance tumor suppression. Eph signaling can be influenced by various factors, including mutations, epigenetic changes, and interactions with other signaling pathways. Eph receptors and ephrins are involved in cell-cell communication, tumor angiogenesis, and tumor microenvironment regulation. Eph signaling can also be used for targeted drug delivery and immunotherapy. The Eph system is a promising target for cancer therapy, with various strategies under evaluation to inhibit or enhance its activity. Understanding the complex roles of Eph signaling in cancer is crucial for developing effective therapeutic approaches.Eph receptors and ephrins are key players in cancer development and progression, with bidirectional signaling between them influencing tumor growth, invasion, angiogenesis, and metastasis. Eph receptors and ephrins are expressed in cancer cells and tumor blood vessels, and their dysregulation can contribute to cancer pathogenesis. Eph signaling is complex, with both promoting and inhibiting effects on tumorigenicity. Eph receptors and ephrins are promising therapeutic targets in cancer, as they can be modulated to suppress tumor growth and enhance tumor suppression. Eph signaling can be influenced by various factors, including mutations, epigenetic changes, and interactions with other signaling pathways. Eph receptors and ephrins are involved in cell-cell communication, tumor angiogenesis, and tumor microenvironment regulation. Eph signaling can also be used for targeted drug delivery and immunotherapy. The Eph system is a promising target for cancer therapy, with various strategies under evaluation to inhibit or enhance its activity. Understanding the complex roles of Eph signaling in cancer is crucial for developing effective therapeutic approaches.