Pancreatic cancer is the seventh leading cause of cancer-related deaths globally, with higher mortality rates in developed countries. It is often diagnosed at an advanced stage due to non-specific symptoms, leading to a 5-year survival rate of 9%. The disease is associated with various risk factors, including smoking, diabetes, obesity, diet, alcohol, age, ethnicity, family history, and chronic pancreatitis. Despite advancements in detection and treatment, incidence is expected to rise, with 355,317 new cases projected by 2040. Screening is not effective for the general population, but targeted groups, especially those with family history, may benefit. Primary prevention is crucial, focusing on lifestyle changes and risk factor reduction. The causes of pancreatic cancer are not fully understood, but modifiable factors like smoking, alcohol, and diet play significant roles. Non-modifiable factors include age, gender, ethnicity, and genetic predisposition. Pancreatic cancer is linked to ABO blood groups and chronic pancreatitis. Early detection remains challenging, and current diagnostic tools have limited effectiveness. Research is needed to improve screening, treatment, and understanding of the disease's etiology and risk factors. Prevention strategies, including lifestyle changes and early detection, are essential to reduce mortality.Pancreatic cancer is the seventh leading cause of cancer-related deaths globally, with higher mortality rates in developed countries. It is often diagnosed at an advanced stage due to non-specific symptoms, leading to a 5-year survival rate of 9%. The disease is associated with various risk factors, including smoking, diabetes, obesity, diet, alcohol, age, ethnicity, family history, and chronic pancreatitis. Despite advancements in detection and treatment, incidence is expected to rise, with 355,317 new cases projected by 2040. Screening is not effective for the general population, but targeted groups, especially those with family history, may benefit. Primary prevention is crucial, focusing on lifestyle changes and risk factor reduction. The causes of pancreatic cancer are not fully understood, but modifiable factors like smoking, alcohol, and diet play significant roles. Non-modifiable factors include age, gender, ethnicity, and genetic predisposition. Pancreatic cancer is linked to ABO blood groups and chronic pancreatitis. Early detection remains challenging, and current diagnostic tools have limited effectiveness. Research is needed to improve screening, treatment, and understanding of the disease's etiology and risk factors. Prevention strategies, including lifestyle changes and early detection, are essential to reduce mortality.