Pancreatic cancer is the seventh leading cause of cancer-related deaths globally, with higher mortality rates in more developed countries. Despite advancements in detection and management, the 5-year survival rate remains low at 9%. The causes of pancreatic carcinoma are not fully understood, but certain risk factors have been identified, including tobacco smoking, diabetes mellitus, obesity, dietary factors, alcohol abuse, age, ethnicity, family history, genetic factors, *Helicobacter pylori* infection, non-O blood group, and chronic pancreatitis. Early detection through screening is challenging due to the lack of early symptoms, and primary prevention is crucial. The incidence and mortality rates vary by region, with Europe and North America having the highest rates. The disease is more common in men and older individuals. Smoking, alcohol consumption, and obesity are significant modifiable risk factors. Dietary factors, such as red and processed meats, also play a role. Non-modifiable risk factors include gender, age, ethnicity, and genetic predispositions. Early detection and prevention strategies, including lifestyle changes and regular health monitoring, are essential for improving outcomes.Pancreatic cancer is the seventh leading cause of cancer-related deaths globally, with higher mortality rates in more developed countries. Despite advancements in detection and management, the 5-year survival rate remains low at 9%. The causes of pancreatic carcinoma are not fully understood, but certain risk factors have been identified, including tobacco smoking, diabetes mellitus, obesity, dietary factors, alcohol abuse, age, ethnicity, family history, genetic factors, *Helicobacter pylori* infection, non-O blood group, and chronic pancreatitis. Early detection through screening is challenging due to the lack of early symptoms, and primary prevention is crucial. The incidence and mortality rates vary by region, with Europe and North America having the highest rates. The disease is more common in men and older individuals. Smoking, alcohol consumption, and obesity are significant modifiable risk factors. Dietary factors, such as red and processed meats, also play a role. Non-modifiable risk factors include gender, age, ethnicity, and genetic predispositions. Early detection and prevention strategies, including lifestyle changes and regular health monitoring, are essential for improving outcomes.