Dengue is a significant mosquito-borne viral disease that has been present for centuries, with symptoms compatible with dengue dating back to the Chin Dynasty (265-420 AD). The virus and its vectors, primarily Aedes aegypti and Aedes albopictus, have become widely distributed in tropical and subtropical regions, leading to significant geographic expansion and increases in incidence, epidemics, and hyperendemicity. Transmission is now present in every WHO region, with over 125 countries endemic for dengue. The true impact of dengue is difficult to determine due to factors such as inadequate surveillance, misdiagnosis, and low reporting rates. Current estimates suggest that the global incidence of dengue infections ranges from 50 million to 200 million, with severe dengue cases occurring in almost 125 countries. The expansion of dengue is expected to continue due to factors such as climate change, globalization, travel, trade, and viral evolution. Effective vector control and improved surveillance are crucial for reducing the disease burden. The WHO's Global Strategy for Dengue Prevention and Control, 2012-2020, aims to reduce the burden of dengue by improving surveillance, advocacy, partnership, and coordination.Dengue is a significant mosquito-borne viral disease that has been present for centuries, with symptoms compatible with dengue dating back to the Chin Dynasty (265-420 AD). The virus and its vectors, primarily Aedes aegypti and Aedes albopictus, have become widely distributed in tropical and subtropical regions, leading to significant geographic expansion and increases in incidence, epidemics, and hyperendemicity. Transmission is now present in every WHO region, with over 125 countries endemic for dengue. The true impact of dengue is difficult to determine due to factors such as inadequate surveillance, misdiagnosis, and low reporting rates. Current estimates suggest that the global incidence of dengue infections ranges from 50 million to 200 million, with severe dengue cases occurring in almost 125 countries. The expansion of dengue is expected to continue due to factors such as climate change, globalization, travel, trade, and viral evolution. Effective vector control and improved surveillance are crucial for reducing the disease burden. The WHO's Global Strategy for Dengue Prevention and Control, 2012-2020, aims to reduce the burden of dengue by improving surveillance, advocacy, partnership, and coordination.