1 June 2020 | Amy Groenewegen, Frans H. Rutten, Arend Mosterd, and Arno W. Hoes
Heart failure is an emerging epidemic, with prevalence and incidence increasing due to an aging population. While incidence has stabilized or decreased in some populations, it has increased in younger individuals, possibly linked to rising obesity. A shift toward heart failure with preserved ejection fraction (HFpEF) is evident, reflecting improved recognition of the condition. Heart failure is increasingly prevalent in low-income countries, where both communicable and lifestyle-related diseases contribute to the burden. Despite declining mortality rates, the epidemic is not over, as the number of patients continues to rise. The epidemiology of heart failure is evolving, with trends in prevalence, incidence, and mortality showing significant variation across populations and regions. HFpEF is more common in women and is often underdiagnosed, while HFrEF is more prevalent in men. Obesity, diabetes, and hypertension are major risk factors, with obesity being particularly linked to HFpEF. Socioeconomic status is a significant determinant of heart failure risk, with deprived populations facing higher incidence and mortality. The global burden of heart failure is substantial, with low- and middle-income countries accounting for a large portion of the disease burden. Mortality rates vary widely, influenced by study design and population characteristics. Heart failure hospitalizations are common, with high readmission rates, often due to comorbidities. The future of heart failure management will require addressing multi-morbidity, improving prevention, and developing targeted therapies for HFpEF. Research in low-income countries is critical to understanding and addressing the growing burden of heart failure.Heart failure is an emerging epidemic, with prevalence and incidence increasing due to an aging population. While incidence has stabilized or decreased in some populations, it has increased in younger individuals, possibly linked to rising obesity. A shift toward heart failure with preserved ejection fraction (HFpEF) is evident, reflecting improved recognition of the condition. Heart failure is increasingly prevalent in low-income countries, where both communicable and lifestyle-related diseases contribute to the burden. Despite declining mortality rates, the epidemic is not over, as the number of patients continues to rise. The epidemiology of heart failure is evolving, with trends in prevalence, incidence, and mortality showing significant variation across populations and regions. HFpEF is more common in women and is often underdiagnosed, while HFrEF is more prevalent in men. Obesity, diabetes, and hypertension are major risk factors, with obesity being particularly linked to HFpEF. Socioeconomic status is a significant determinant of heart failure risk, with deprived populations facing higher incidence and mortality. The global burden of heart failure is substantial, with low- and middle-income countries accounting for a large portion of the disease burden. Mortality rates vary widely, influenced by study design and population characteristics. Heart failure hospitalizations are common, with high readmission rates, often due to comorbidities. The future of heart failure management will require addressing multi-morbidity, improving prevention, and developing targeted therapies for HFpEF. Research in low-income countries is critical to understanding and addressing the growing burden of heart failure.