Methicillin-resistant Staphylococcus aureus (MRSA) infections have increased in both hospital and community settings globally. MRSA is a significant cause of morbidity and mortality, with over 19,000 deaths annually in the U.S. from hospital-acquired MRSA infections. Community-associated MRSA (CA-MRSA) has also emerged, particularly in previously healthy individuals, and is often resistant to non-β-lactam antibiotics. CA-MRSA strains, such as the USA300 clone, are associated with severe infections like necrotizing fasciitis, septic thrombophlebitis, and post-influenza pneumonia. CA-MRSA can spread through person-to-person contact, and outbreaks have been reported in various populations, including athletes, men who have sex with men, and prison inmates. The rise of MRSA is attributed to factors such as antibiotic overuse, medical interventions, and the pathogen's ability to adapt. Recent studies show that CA-MRSA is increasingly found in healthcare settings, complicating treatment and increasing mortality. Understanding the mechanisms of resistance and transmission is crucial for managing MRSA infections. The article highlights the growing burden of MRSA on healthcare systems and the need for improved prevention and treatment strategies.Methicillin-resistant Staphylococcus aureus (MRSA) infections have increased in both hospital and community settings globally. MRSA is a significant cause of morbidity and mortality, with over 19,000 deaths annually in the U.S. from hospital-acquired MRSA infections. Community-associated MRSA (CA-MRSA) has also emerged, particularly in previously healthy individuals, and is often resistant to non-β-lactam antibiotics. CA-MRSA strains, such as the USA300 clone, are associated with severe infections like necrotizing fasciitis, septic thrombophlebitis, and post-influenza pneumonia. CA-MRSA can spread through person-to-person contact, and outbreaks have been reported in various populations, including athletes, men who have sex with men, and prison inmates. The rise of MRSA is attributed to factors such as antibiotic overuse, medical interventions, and the pathogen's ability to adapt. Recent studies show that CA-MRSA is increasingly found in healthcare settings, complicating treatment and increasing mortality. Understanding the mechanisms of resistance and transmission is crucial for managing MRSA infections. The article highlights the growing burden of MRSA on healthcare systems and the need for improved prevention and treatment strategies.