Pancreatic cancer remains one of the deadliest cancers, with over 331,000 deaths annually, ranking as the seventh leading cause of cancer death globally. It is the 11th most common cancer, with the highest incidence and mortality rates in developed countries. The overall five-year survival rate is about 6%, with small variations between developed and developing countries. Risk factors include smoking, obesity, diabetes, diet, and physical inactivity. There are no current screening recommendations, making primary prevention crucial. Understanding the etiology and risk factors is essential for prevention. Pancreatic cancer incidence varies globally, with the highest rates in Northern America and Western Europe, and the lowest in Middle Africa and South-Central Asia. Men have higher incidence rates than women, with the highest risk in certain countries. Mortality rates also vary, with the highest in Northern America and Western Europe, and the lowest in some African and Pacific regions. Mortality increases with age, with almost 90% of deaths occurring after 55 years. Temporal trends show that mortality rates have increased in many countries, while in others, they have decreased. Smoking is a major contributor to high mortality rates, and reduced smoking has been linked to declining mortality in developed countries. However, recent increases in some European countries suggest other factors, such as obesity and diabetes, may also play a role. Lifestyle changes in developing countries are contributing to rising cancer rates. Survival rates are low, with about 6% five-year survival, with small variations between developed and developing countries. Survival is influenced by factors such as cancer type, stage, and treatment. Risk factors include smoking, obesity, diabetes, diet, and physical inactivity. Prevention strategies focus on lifestyle changes, such as quitting smoking, maintaining a healthy weight, and eating a balanced diet. Chemoprevention with agents like COX inhibitors and aspirin may help high-risk individuals. Screening for pancreatic cancer is not currently available, and early detection remains challenging. Research is ongoing to develop effective screening methods, particularly for high-risk populations. Despite advances in treatment, survival rates remain low due to late diagnosis and the advanced stage at which cancer is often found. Prevention remains the key to reducing the burden of pancreatic cancer.Pancreatic cancer remains one of the deadliest cancers, with over 331,000 deaths annually, ranking as the seventh leading cause of cancer death globally. It is the 11th most common cancer, with the highest incidence and mortality rates in developed countries. The overall five-year survival rate is about 6%, with small variations between developed and developing countries. Risk factors include smoking, obesity, diabetes, diet, and physical inactivity. There are no current screening recommendations, making primary prevention crucial. Understanding the etiology and risk factors is essential for prevention. Pancreatic cancer incidence varies globally, with the highest rates in Northern America and Western Europe, and the lowest in Middle Africa and South-Central Asia. Men have higher incidence rates than women, with the highest risk in certain countries. Mortality rates also vary, with the highest in Northern America and Western Europe, and the lowest in some African and Pacific regions. Mortality increases with age, with almost 90% of deaths occurring after 55 years. Temporal trends show that mortality rates have increased in many countries, while in others, they have decreased. Smoking is a major contributor to high mortality rates, and reduced smoking has been linked to declining mortality in developed countries. However, recent increases in some European countries suggest other factors, such as obesity and diabetes, may also play a role. Lifestyle changes in developing countries are contributing to rising cancer rates. Survival rates are low, with about 6% five-year survival, with small variations between developed and developing countries. Survival is influenced by factors such as cancer type, stage, and treatment. Risk factors include smoking, obesity, diabetes, diet, and physical inactivity. Prevention strategies focus on lifestyle changes, such as quitting smoking, maintaining a healthy weight, and eating a balanced diet. Chemoprevention with agents like COX inhibitors and aspirin may help high-risk individuals. Screening for pancreatic cancer is not currently available, and early detection remains challenging. Research is ongoing to develop effective screening methods, particularly for high-risk populations. Despite advances in treatment, survival rates remain low due to late diagnosis and the advanced stage at which cancer is often found. Prevention remains the key to reducing the burden of pancreatic cancer.