Pancreatic cancer remains one of the deadliest cancers, causing over 331,000 deaths annually and ranking as the seventh leading cause of cancer death globally. The highest incidence and mortality rates are found in developed countries. Tobacco smoking is a known risk factor, likely explaining some international variations and gender differences. The overall five-year survival rate is about 6%, with minimal variation between developed and developing countries. The causes of pancreatic cancer are still not fully understood, but certain risk factors include smoking, obesity, genetics, diabetes, diet, inactivity, and alcohol consumption. There are no current screening recommendations, so primary prevention is crucial. Understanding the etiology and identifying risk factors is essential for developing effective prevention strategies.Pancreatic cancer remains one of the deadliest cancers, causing over 331,000 deaths annually and ranking as the seventh leading cause of cancer death globally. The highest incidence and mortality rates are found in developed countries. Tobacco smoking is a known risk factor, likely explaining some international variations and gender differences. The overall five-year survival rate is about 6%, with minimal variation between developed and developing countries. The causes of pancreatic cancer are still not fully understood, but certain risk factors include smoking, obesity, genetics, diabetes, diet, inactivity, and alcohol consumption. There are no current screening recommendations, so primary prevention is crucial. Understanding the etiology and identifying risk factors is essential for developing effective prevention strategies.