The study by Yeager, Glass, Neff, and Brinck-Johnsen evaluated the effects of epidural anesthesia and analgesia (EAA) on postoperative morbidity in high-risk surgical patients. A total of 53 patients were included, with 28 receiving EAA and 25 receiving standard anesthetic and analgesic techniques. The results showed that patients who received EAA had a significantly reduced overall postoperative complication rate (P = 0.002), incidence of cardiovascular failure (P = 0.007), and major infectious complications (P = 0.007). Urinary cortisol excretion, a marker of stress response, was significantly lower in the EAA group during the first 24 postoperative hours (P = 0.025). Additionally, hospital costs were significantly reduced for patients who received EAA (P = 0.02). The authors concluded that EAA significantly improved operative outcomes in high-risk surgical patients.The study by Yeager, Glass, Neff, and Brinck-Johnsen evaluated the effects of epidural anesthesia and analgesia (EAA) on postoperative morbidity in high-risk surgical patients. A total of 53 patients were included, with 28 receiving EAA and 25 receiving standard anesthetic and analgesic techniques. The results showed that patients who received EAA had a significantly reduced overall postoperative complication rate (P = 0.002), incidence of cardiovascular failure (P = 0.007), and major infectious complications (P = 0.007). Urinary cortisol excretion, a marker of stress response, was significantly lower in the EAA group during the first 24 postoperative hours (P = 0.025). Additionally, hospital costs were significantly reduced for patients who received EAA (P = 0.02). The authors concluded that EAA significantly improved operative outcomes in high-risk surgical patients.