A randomized controlled trial evaluated the effects of epidural anesthesia and postoperative analgesia (EAA) on postoperative morbidity in high-risk surgical patients. Fifty-three patients were enrolled, with 28 receiving EAA and 25 receiving standard anesthetic and analgesic techniques. Preoperative surgical risk was comparable between groups. Patients receiving EAA had significantly reduced postoperative complication rates, including cardiovascular failure and major infectious complications. Urinary cortisol excretion was also reduced in the first 24 postoperative hours, and hospital costs were lower for EAA patients. The study concluded that EAA significantly improved operative outcomes in high-risk surgical patients. The study compared EAA with general anesthesia and standard analgesic techniques. Patients in the EAA group had a lower incidence of postoperative complications, including cardiovascular and infectious issues. EAA also reduced the need for postoperative mechanical ventilation and hospital costs. The cardiovascular benefits of EAA were attributed to improved pain control, reduced preload, and a lower overall complication rate. Additionally, EAA may have reduced the incidence of major infectious complications by decreasing the duration of endotracheal intubation and mechanical ventilation, which can impair lung defense mechanisms. The study also found that EAA reduced the stress response, potentially improving immunocompetence. The results showed that EAA significantly reduced postoperative morbidity and improved operative outcomes in high-risk surgical patients. The study highlights the potential benefits of EAA in reducing complications, improving recovery, and lowering healthcare costs. The findings support the use of EAA in high-risk surgical patients to enhance postoperative outcomes.A randomized controlled trial evaluated the effects of epidural anesthesia and postoperative analgesia (EAA) on postoperative morbidity in high-risk surgical patients. Fifty-three patients were enrolled, with 28 receiving EAA and 25 receiving standard anesthetic and analgesic techniques. Preoperative surgical risk was comparable between groups. Patients receiving EAA had significantly reduced postoperative complication rates, including cardiovascular failure and major infectious complications. Urinary cortisol excretion was also reduced in the first 24 postoperative hours, and hospital costs were lower for EAA patients. The study concluded that EAA significantly improved operative outcomes in high-risk surgical patients. The study compared EAA with general anesthesia and standard analgesic techniques. Patients in the EAA group had a lower incidence of postoperative complications, including cardiovascular and infectious issues. EAA also reduced the need for postoperative mechanical ventilation and hospital costs. The cardiovascular benefits of EAA were attributed to improved pain control, reduced preload, and a lower overall complication rate. Additionally, EAA may have reduced the incidence of major infectious complications by decreasing the duration of endotracheal intubation and mechanical ventilation, which can impair lung defense mechanisms. The study also found that EAA reduced the stress response, potentially improving immunocompetence. The results showed that EAA significantly reduced postoperative morbidity and improved operative outcomes in high-risk surgical patients. The study highlights the potential benefits of EAA in reducing complications, improving recovery, and lowering healthcare costs. The findings support the use of EAA in high-risk surgical patients to enhance postoperative outcomes.