Epigenetic reprogramming occurs in both plants and animals during development, involving widespread changes in DNA methylation, histone modifications, and small RNA-mediated inheritance. In plants, such reprogramming is essential for maintaining genome stability, imprinting, and transposon silencing. In mammals, it is crucial for resetting epigenetic marks during gametogenesis and early embryonic development to ensure proper gene expression and prevent the transmission of harmful epigenetic states. Key mechanisms include DNA demethylation, histone modification, and the action of small RNAs. In Arabidopsis, DNA methylation is maintained by specific enzymes, while in mammals, de novo methyltransferases and repair pathways are involved. Histone modifications also play a role in epigenetic reprogramming, with some marks being reset in each generation. In both plants and animals, epigenetic reprogramming helps to establish and maintain genomic integrity, control gene expression, and ensure proper development. The study highlights the similarities and differences in reprogramming mechanisms between plants and mammals, emphasizing the importance of these processes in developmental and reproductive strategies.Epigenetic reprogramming occurs in both plants and animals during development, involving widespread changes in DNA methylation, histone modifications, and small RNA-mediated inheritance. In plants, such reprogramming is essential for maintaining genome stability, imprinting, and transposon silencing. In mammals, it is crucial for resetting epigenetic marks during gametogenesis and early embryonic development to ensure proper gene expression and prevent the transmission of harmful epigenetic states. Key mechanisms include DNA demethylation, histone modification, and the action of small RNAs. In Arabidopsis, DNA methylation is maintained by specific enzymes, while in mammals, de novo methyltransferases and repair pathways are involved. Histone modifications also play a role in epigenetic reprogramming, with some marks being reset in each generation. In both plants and animals, epigenetic reprogramming helps to establish and maintain genomic integrity, control gene expression, and ensure proper development. The study highlights the similarities and differences in reprogramming mechanisms between plants and mammals, emphasizing the importance of these processes in developmental and reproductive strategies.