The article discusses the mechanisms and significance of epigenetic reprogramming in both plants and animals. Epigenetic modifications, such as DNA methylation and histone modifications, play crucial roles in gene silencing, imprinting, and transposon control. In plants, epigenetic reprogramming occurs in non-germ line reproductive cells, while in animals, it happens in primordial germ cells (PGCs) and early embryos. Key processes include DNA demethylation, histone modification reset, and the involvement of small RNAs. The article highlights the conservation and differences in epigenetic reprogramming between plants and animals, emphasizing its importance in maintaining genome integrity and preventing detrimental epialleles from accumulating over generations. Experimental reprogramming methods, such as cell fusion and transcription factor-driven reprogramming, are also discussed, along with their implications for regenerative medicine and understanding the pluripotency state.The article discusses the mechanisms and significance of epigenetic reprogramming in both plants and animals. Epigenetic modifications, such as DNA methylation and histone modifications, play crucial roles in gene silencing, imprinting, and transposon control. In plants, epigenetic reprogramming occurs in non-germ line reproductive cells, while in animals, it happens in primordial germ cells (PGCs) and early embryos. Key processes include DNA demethylation, histone modification reset, and the involvement of small RNAs. The article highlights the conservation and differences in epigenetic reprogramming between plants and animals, emphasizing its importance in maintaining genome integrity and preventing detrimental epialleles from accumulating over generations. Experimental reprogramming methods, such as cell fusion and transcription factor-driven reprogramming, are also discussed, along with their implications for regenerative medicine and understanding the pluripotency state.