Astrocytes play a crucial role in learning and memory by regulating synaptic transmission, calcium dynamics, and metabolic interactions with neurons. They are involved in maintaining brain homeostasis, supporting neuronal function, and modulating synaptic plasticity. Astrocytes communicate with neurons through gap junctions and release gliotransmitters such as glutamate, ATP, and D-serine, which influence synaptic activity and plasticity. They also regulate brain rhythms essential for cognition and contribute to memory consolidation through metabolic coupling with neurons. Astrocytes are involved in synaptogenesis, synaptic modulation, and neuromodulation, and their dysfunction is linked to neurodegenerative diseases like Alzheimer's. Recent studies highlight the importance of astrocytic calcium signaling in memory formation and retrieval, as well as in the regulation of synaptic activity. Astrocytes also support adult neurogenesis, which is critical for learning and memory. The role of astrocytes in learning and memory is increasingly recognized, with their involvement in various cognitive processes, including working memory, recognition memory, and contextual memory. Dysfunction in astrocytic calcium signaling and metabolism is associated with memory impairments and neurodegenerative diseases. Targeting astrocytic signaling pathways offers potential therapeutic strategies for cognitive disorders.Astrocytes play a crucial role in learning and memory by regulating synaptic transmission, calcium dynamics, and metabolic interactions with neurons. They are involved in maintaining brain homeostasis, supporting neuronal function, and modulating synaptic plasticity. Astrocytes communicate with neurons through gap junctions and release gliotransmitters such as glutamate, ATP, and D-serine, which influence synaptic activity and plasticity. They also regulate brain rhythms essential for cognition and contribute to memory consolidation through metabolic coupling with neurons. Astrocytes are involved in synaptogenesis, synaptic modulation, and neuromodulation, and their dysfunction is linked to neurodegenerative diseases like Alzheimer's. Recent studies highlight the importance of astrocytic calcium signaling in memory formation and retrieval, as well as in the regulation of synaptic activity. Astrocytes also support adult neurogenesis, which is critical for learning and memory. The role of astrocytes in learning and memory is increasingly recognized, with their involvement in various cognitive processes, including working memory, recognition memory, and contextual memory. Dysfunction in astrocytic calcium signaling and metabolism is associated with memory impairments and neurodegenerative diseases. Targeting astrocytic signaling pathways offers potential therapeutic strategies for cognitive disorders.