This study compared health-related quality of life (HQOL) and depression in prostate cancer patients who had undergone radical prostatectomy or hormonal therapy more than 6 months prior. A total of 116 patients participated, including 83 who had undergone radical prostatectomy and 33 who had received hormonal therapy. Data were collected using the Expanded Prostate Cancer Index Composite (EPIC) and the Geriatric Depression Scale Short Form (GDS). Results showed that patients who had undergone hormonal therapy reported significantly higher HQOL scores than those who had undergone radical prostatectomy (p = .002). Significant differences were observed in urinary function, incontinence, and sexual bother. Depression levels were not significantly different between the two groups, but moderate negative correlations were found between HQOL and depression in both groups. The study concluded that many prostate cancer patients experienced functional deterioration in urinary and sexual domains and were more depressed than 6 months after treatment. Clinicians should evaluate patients' complaints based on their treatment modality and intervene accordingly. Keywords: Prostatic Neoplasms, Quality of Life, Depression, Prostatectomy, Hormone Replacement Therapy.This study compared health-related quality of life (HQOL) and depression in prostate cancer patients who had undergone radical prostatectomy or hormonal therapy more than 6 months prior. A total of 116 patients participated, including 83 who had undergone radical prostatectomy and 33 who had received hormonal therapy. Data were collected using the Expanded Prostate Cancer Index Composite (EPIC) and the Geriatric Depression Scale Short Form (GDS). Results showed that patients who had undergone hormonal therapy reported significantly higher HQOL scores than those who had undergone radical prostatectomy (p = .002). Significant differences were observed in urinary function, incontinence, and sexual bother. Depression levels were not significantly different between the two groups, but moderate negative correlations were found between HQOL and depression in both groups. The study concluded that many prostate cancer patients experienced functional deterioration in urinary and sexual domains and were more depressed than 6 months after treatment. Clinicians should evaluate patients' complaints based on their treatment modality and intervene accordingly. Keywords: Prostatic Neoplasms, Quality of Life, Depression, Prostatectomy, Hormone Replacement Therapy.