This study estimates the global burden of endemic canine rabies, finding that it causes approximately 59,000 human deaths annually, over 3.7 million disability-adjusted life years (DALYs), and 8.6 billion USD in economic losses. The highest risk of rabies is in the poorest regions, where vaccination coverage is low and access to post-exposure prophylaxis (PEP) is limited. The economic burden is mainly due to premature death (55%), followed by direct PEP costs (20%) and lost income while seeking PEP (15.5%). The study highlights the need for increased investment in dog vaccination, which is the most effective way to reduce the disease burden. It also emphasizes the importance of improved surveillance to better estimate the burden and monitor control efforts. The findings show that rabies remains a significant public health issue in many developing countries, with limited resources and infrastructure for effective control. The study underscores the need for collaborative efforts between medical and veterinary sectors to reduce the disease burden. The results indicate that rabies is a preventable disease, but current control measures are insufficient. The study provides a comprehensive estimate of the disease burden, highlighting the need for improved data collection and reporting to better understand and address the issue. The findings also emphasize the importance of addressing the economic and social impacts of rabies, particularly in low-income countries. The study concludes that increased investment in dog vaccination and improved access to PEP are essential to reducing the burden of rabies. The results highlight the need for global collaboration and funding to combat rabies effectively.This study estimates the global burden of endemic canine rabies, finding that it causes approximately 59,000 human deaths annually, over 3.7 million disability-adjusted life years (DALYs), and 8.6 billion USD in economic losses. The highest risk of rabies is in the poorest regions, where vaccination coverage is low and access to post-exposure prophylaxis (PEP) is limited. The economic burden is mainly due to premature death (55%), followed by direct PEP costs (20%) and lost income while seeking PEP (15.5%). The study highlights the need for increased investment in dog vaccination, which is the most effective way to reduce the disease burden. It also emphasizes the importance of improved surveillance to better estimate the burden and monitor control efforts. The findings show that rabies remains a significant public health issue in many developing countries, with limited resources and infrastructure for effective control. The study underscores the need for collaborative efforts between medical and veterinary sectors to reduce the disease burden. The results indicate that rabies is a preventable disease, but current control measures are insufficient. The study provides a comprehensive estimate of the disease burden, highlighting the need for improved data collection and reporting to better understand and address the issue. The findings also emphasize the importance of addressing the economic and social impacts of rabies, particularly in low-income countries. The study concludes that increased investment in dog vaccination and improved access to PEP are essential to reducing the burden of rabies. The results highlight the need for global collaboration and funding to combat rabies effectively.