Resin-based composites and sealants used in dentistry may have estrogenic activity, as shown by studies on bisphenol-A (BPA) and bisphenol-A dimethacrylate (Bis-GMA). These compounds, found in dental materials, can leach into saliva and contribute to human exposure to xenoestrogens. The study tested a bis-GMA-based sealant and found BPA in saliva samples, indicating potential estrogenic effects. BPA and Bis-GMA were identified as estrogenic in MCF7 breast cancer cells, increasing cell proliferation and progesterone receptor expression. The estrogenic activity was attributed to BPA and Bis-GMA, which are components of dental composites and sealants. The study also found that BPA and its derivatives can be released into saliva after dental treatment, raising concerns about human exposure to xenoestrogens. The research highlights the need for further investigation into the health effects of these compounds, particularly in children. The study underscores the importance of reevaluating the use of bis-GMA-based materials in dentistry due to their potential estrogenic effects.Resin-based composites and sealants used in dentistry may have estrogenic activity, as shown by studies on bisphenol-A (BPA) and bisphenol-A dimethacrylate (Bis-GMA). These compounds, found in dental materials, can leach into saliva and contribute to human exposure to xenoestrogens. The study tested a bis-GMA-based sealant and found BPA in saliva samples, indicating potential estrogenic effects. BPA and Bis-GMA were identified as estrogenic in MCF7 breast cancer cells, increasing cell proliferation and progesterone receptor expression. The estrogenic activity was attributed to BPA and Bis-GMA, which are components of dental composites and sealants. The study also found that BPA and its derivatives can be released into saliva after dental treatment, raising concerns about human exposure to xenoestrogens. The research highlights the need for further investigation into the health effects of these compounds, particularly in children. The study underscores the importance of reevaluating the use of bis-GMA-based materials in dentistry due to their potential estrogenic effects.