The article explores the ethical dilemmas posed by the rise of artificial intelligence (AI) from a transhumanist perspective. It highlights the significant differences between humans, transhumans, and AI, which generate various ethical and spiritual-transcendent dilemmas that could potentially make AI a threat to humanity. Concepts such as singularity, autonomy, consciousness, decision-making, and freedom are discussed to illustrate the distinction between a programmed machine and human autonomy. The authors conclude that not all techno-scientific possibilities are ethically acceptable, and it is impossible to equate a machine programmed by algorithms with a human capable of self-awareness, self-determination, and a sense of uniqueness. The study uses documentary and hermeneutic research methods, complemented by responses from ChatGPT 5.5 in Spanish, to triangulate findings. The article also examines the implications of AI in various fields, including education and industry, and discusses the need for ethical regulation and the preservation of human dignity in the face of technological advancements.The article explores the ethical dilemmas posed by the rise of artificial intelligence (AI) from a transhumanist perspective. It highlights the significant differences between humans, transhumans, and AI, which generate various ethical and spiritual-transcendent dilemmas that could potentially make AI a threat to humanity. Concepts such as singularity, autonomy, consciousness, decision-making, and freedom are discussed to illustrate the distinction between a programmed machine and human autonomy. The authors conclude that not all techno-scientific possibilities are ethically acceptable, and it is impossible to equate a machine programmed by algorithms with a human capable of self-awareness, self-determination, and a sense of uniqueness. The study uses documentary and hermeneutic research methods, complemented by responses from ChatGPT 5.5 in Spanish, to triangulate findings. The article also examines the implications of AI in various fields, including education and industry, and discusses the need for ethical regulation and the preservation of human dignity in the face of technological advancements.