A systematic review of barriers to adopting telemedicine worldwide identified 33 barriers, with technical staff challenges (11%), resistance to change (8%), cost (8%), reimbursement (5%), age of patient (5%), and level of education of patient (5%) as the most common. These barriers varied by country, organization, patient, and medical staff. The review analyzed 30 articles from CINAHL and PubMed, highlighting the need for training, change management, and hybrid delivery models to overcome these challenges. Telemedicine offers benefits like improved access to healthcare, reduced travel time, and cost savings, but its adoption is hindered by factors such as lack of high-speed internet, poor application design, and privacy concerns. The study emphasizes the importance of policy interventions to address these barriers, particularly in rural and low-income areas. It also notes that public policy may not be effective in addressing age-related resistance to telemedicine, and that incentives and education are needed to encourage adoption. The review concludes that while telemedicine has potential, its successful implementation requires addressing technical, organizational, and patient-specific barriers through targeted policies and strategies.A systematic review of barriers to adopting telemedicine worldwide identified 33 barriers, with technical staff challenges (11%), resistance to change (8%), cost (8%), reimbursement (5%), age of patient (5%), and level of education of patient (5%) as the most common. These barriers varied by country, organization, patient, and medical staff. The review analyzed 30 articles from CINAHL and PubMed, highlighting the need for training, change management, and hybrid delivery models to overcome these challenges. Telemedicine offers benefits like improved access to healthcare, reduced travel time, and cost savings, but its adoption is hindered by factors such as lack of high-speed internet, poor application design, and privacy concerns. The study emphasizes the importance of policy interventions to address these barriers, particularly in rural and low-income areas. It also notes that public policy may not be effective in addressing age-related resistance to telemedicine, and that incentives and education are needed to encourage adoption. The review concludes that while telemedicine has potential, its successful implementation requires addressing technical, organizational, and patient-specific barriers through targeted policies and strategies.