This systematic review evaluates the barriers to adopting telemedicine worldwide, analyzing 30 articles from CINAHL and PubMed. The study identifies 33 barriers, with the most frequent being technical challenges (11%), resistance to change (8%), cost (8%), reimbursement (5%), patient age (5%), and patient education level (5%). The barriers are categorized into organizational, patient, and staff programmer-specific issues. The review highlights that while telemedicine offers significant benefits, such as increased access to healthcare and cost savings, it faces widespread adoption challenges. The study recommends policy interventions to address these barriers, particularly in developing countries, and suggests that public policy could play a crucial role in facilitating the diffusion of telemedicine.This systematic review evaluates the barriers to adopting telemedicine worldwide, analyzing 30 articles from CINAHL and PubMed. The study identifies 33 barriers, with the most frequent being technical challenges (11%), resistance to change (8%), cost (8%), reimbursement (5%), patient age (5%), and patient education level (5%). The barriers are categorized into organizational, patient, and staff programmer-specific issues. The review highlights that while telemedicine offers significant benefits, such as increased access to healthcare and cost savings, it faces widespread adoption challenges. The study recommends policy interventions to address these barriers, particularly in developing countries, and suggests that public policy could play a crucial role in facilitating the diffusion of telemedicine.