This study evaluates the anti-aging properties of empagliflozin (EMP) in mice. The mice were divided into four groups: a negative control group receiving normal saline without D-galactose (DGA), a DGA-induced aging group, a vitamin C treatment group, and an EMP treatment group. The results showed that EMP significantly reduced levels of TNF-α, IL-1β, and MDA compared to the DGA-induced group, while increasing GSH-Px levels. Additionally, EMP increased the levels of COL-1 and COL-3 compared to the DGA-induced group. The study concluded that EMP positively affects several aging parameters in mice, including reducing myocytic weight, improving skin vitality by increasing collagen levels, decreasing inflammatory mediators, and enhancing antioxidant activity. The findings suggest that EMP may have potential as an anti-aging treatment.This study evaluates the anti-aging properties of empagliflozin (EMP) in mice. The mice were divided into four groups: a negative control group receiving normal saline without D-galactose (DGA), a DGA-induced aging group, a vitamin C treatment group, and an EMP treatment group. The results showed that EMP significantly reduced levels of TNF-α, IL-1β, and MDA compared to the DGA-induced group, while increasing GSH-Px levels. Additionally, EMP increased the levels of COL-1 and COL-3 compared to the DGA-induced group. The study concluded that EMP positively affects several aging parameters in mice, including reducing myocytic weight, improving skin vitality by increasing collagen levels, decreasing inflammatory mediators, and enhancing antioxidant activity. The findings suggest that EMP may have potential as an anti-aging treatment.