This article presents evidence-based guidelines for the management of osteoporosis in men, developed by an international multidisciplinary working group. Historically, osteoporosis has been predominantly studied and managed in women, leading to underdiagnosis and undertreatment in men. The guidelines address the diagnosis, monitoring, and treatment of osteoporosis in men, based on the latest research and expert opinion. Key recommendations include using a female reference database for densitometric diagnosis, employing FRAX for fracture risk assessment, and considering intervention thresholds that vary with age. Treatment options are recommended, including bisphosphonates, denosumab, and anabolic agents like teriparatide and abaloparatide. The guidelines also emphasize the importance of physical activity, a balanced diet, and hormone replacement therapy in managing osteoporosis in men. The economic burden of osteoporosis in men is significant, and cost-effective interventions are outlined. Patient perspectives highlight the desire for prompt treatment to prevent further fractures. The guidelines aim to improve the diagnosis and management of osteoporosis in men, addressing the need for more research and investment in this area.This article presents evidence-based guidelines for the management of osteoporosis in men, developed by an international multidisciplinary working group. Historically, osteoporosis has been predominantly studied and managed in women, leading to underdiagnosis and undertreatment in men. The guidelines address the diagnosis, monitoring, and treatment of osteoporosis in men, based on the latest research and expert opinion. Key recommendations include using a female reference database for densitometric diagnosis, employing FRAX for fracture risk assessment, and considering intervention thresholds that vary with age. Treatment options are recommended, including bisphosphonates, denosumab, and anabolic agents like teriparatide and abaloparatide. The guidelines also emphasize the importance of physical activity, a balanced diet, and hormone replacement therapy in managing osteoporosis in men. The economic burden of osteoporosis in men is significant, and cost-effective interventions are outlined. Patient perspectives highlight the desire for prompt treatment to prevent further fractures. The guidelines aim to improve the diagnosis and management of osteoporosis in men, addressing the need for more research and investment in this area.