Since January 2020, Elsevier has established a COVID-19 resource center on Elsevier Connect, providing free information in English and Mandarin about the novel coronavirus. The company has granted permission to make all COVID-19-related research available in PubMed Central and other public repositories, allowing unrestricted reuse and analysis with acknowledgment of the original source. A study by Fei Xiao et al. from Sun Yat-sen University in Zhuhai, China, investigates the gastrointestinal infection of SARS-CoV-2 and its potential fecal-oral transmission route. The study found that 53.42% of 73 hospitalized patients tested positive for SARS-CoV-2 RNA in their stools, with positive results lasting from 1 to 12 days. Gastrointestinal endoscopy revealed no significant damage to the mucous epithelium but showed the presence of ACE2, a viral receptor, in the cytoplasm of gastric, duodenal, and rectal epithelial cells. The study suggests that SARS-CoV-2 can infect these gastrointestinal glandular epithelial cells and that fecal-oral transmission could be an additional route of viral spread. The authors recommend routine testing of viral RNA in feces to monitor infectious virions and to continue transmission-based precautions if fecal tests are positive.Since January 2020, Elsevier has established a COVID-19 resource center on Elsevier Connect, providing free information in English and Mandarin about the novel coronavirus. The company has granted permission to make all COVID-19-related research available in PubMed Central and other public repositories, allowing unrestricted reuse and analysis with acknowledgment of the original source. A study by Fei Xiao et al. from Sun Yat-sen University in Zhuhai, China, investigates the gastrointestinal infection of SARS-CoV-2 and its potential fecal-oral transmission route. The study found that 53.42% of 73 hospitalized patients tested positive for SARS-CoV-2 RNA in their stools, with positive results lasting from 1 to 12 days. Gastrointestinal endoscopy revealed no significant damage to the mucous epithelium but showed the presence of ACE2, a viral receptor, in the cytoplasm of gastric, duodenal, and rectal epithelial cells. The study suggests that SARS-CoV-2 can infect these gastrointestinal glandular epithelial cells and that fecal-oral transmission could be an additional route of viral spread. The authors recommend routine testing of viral RNA in feces to monitor infectious virions and to continue transmission-based precautions if fecal tests are positive.