Hydrogels, hydrophilic polymer networks that can absorb and retain aqueous fluids, hold significant promise in biomedical applications due to their high water content, permeability, and structural similarity to the extracellular matrix. Recent advancements in chemical techniques have enhanced their versatility, allowing for the integration of molecules that guide cellular activities and enabling controlled activation under time constraints. However, conventional synthetic hydrogels suffer from inherent weaknesses such as heterogeneity and network imperfections, which affect their mechanical properties, diffusion rates, and biological activity. To address these challenges, hybrid hydrogels have emerged, aiming to improve strength, drug release efficiency, and therapeutic effectiveness. These hybrid hydrogels, featuring improved formulations, are tailored for controlled drug release and tissue regeneration across both soft and hard tissues. This review delves into recent advancements in hybrid hydrogel systems, covering diverse types, modification strategies, and the integration of nano/microstructures. It discusses innovative fabrication techniques such as click reactions, 3D printing, and photopatterning, along with the release mechanisms of bioactive molecules. By addressing challenges, the review emphasizes diverse biomedical applications and envisions a promising future for hybrid hydrogels in various biomedical fields.Hydrogels, hydrophilic polymer networks that can absorb and retain aqueous fluids, hold significant promise in biomedical applications due to their high water content, permeability, and structural similarity to the extracellular matrix. Recent advancements in chemical techniques have enhanced their versatility, allowing for the integration of molecules that guide cellular activities and enabling controlled activation under time constraints. However, conventional synthetic hydrogels suffer from inherent weaknesses such as heterogeneity and network imperfections, which affect their mechanical properties, diffusion rates, and biological activity. To address these challenges, hybrid hydrogels have emerged, aiming to improve strength, drug release efficiency, and therapeutic effectiveness. These hybrid hydrogels, featuring improved formulations, are tailored for controlled drug release and tissue regeneration across both soft and hard tissues. This review delves into recent advancements in hybrid hydrogel systems, covering diverse types, modification strategies, and the integration of nano/microstructures. It discusses innovative fabrication techniques such as click reactions, 3D printing, and photopatterning, along with the release mechanisms of bioactive molecules. By addressing challenges, the review emphasizes diverse biomedical applications and envisions a promising future for hybrid hydrogels in various biomedical fields.