Hybrid hydrogels are advanced biomaterials with significant potential in drug delivery and tissue engineering. They combine the advantages of natural and synthetic polymers to enhance mechanical strength, drug release efficiency, and therapeutic effectiveness. This review discusses recent advancements in hybrid hydrogel systems, including their types, modification strategies, and integration of nano/microstructures. The review highlights innovative fabrication techniques such as click reactions, 3D printing, and photopatterning, along with the mechanisms of bioactive molecule release. It emphasizes the diverse biomedical applications of hybrid hydrogels and their promising future in various fields. The review also covers the basic architecture of hydrogels, the polymers used in their fabrication, and the modification strategies to improve their properties. Natural and synthetic polymers, such as polysaccharides, proteins, and synthetic materials like PEG, PCL, and PLA, are discussed in detail. The review explores different types of hybrid hydrogels, including reversible physical hydrogels, multifunctional nanogels, self-assembling hydrogels, chemically crosslinked hydrogels, core-shell polymeric networks, and supramolecular hydrogels. Each type is analyzed for its unique properties and applications in biomedical fields. The review also addresses the challenges and future directions for hybrid hydrogels in drug delivery and tissue engineering.Hybrid hydrogels are advanced biomaterials with significant potential in drug delivery and tissue engineering. They combine the advantages of natural and synthetic polymers to enhance mechanical strength, drug release efficiency, and therapeutic effectiveness. This review discusses recent advancements in hybrid hydrogel systems, including their types, modification strategies, and integration of nano/microstructures. The review highlights innovative fabrication techniques such as click reactions, 3D printing, and photopatterning, along with the mechanisms of bioactive molecule release. It emphasizes the diverse biomedical applications of hybrid hydrogels and their promising future in various fields. The review also covers the basic architecture of hydrogels, the polymers used in their fabrication, and the modification strategies to improve their properties. Natural and synthetic polymers, such as polysaccharides, proteins, and synthetic materials like PEG, PCL, and PLA, are discussed in detail. The review explores different types of hybrid hydrogels, including reversible physical hydrogels, multifunctional nanogels, self-assembling hydrogels, chemically crosslinked hydrogels, core-shell polymeric networks, and supramolecular hydrogels. Each type is analyzed for its unique properties and applications in biomedical fields. The review also addresses the challenges and future directions for hybrid hydrogels in drug delivery and tissue engineering.