The review highlights the importance of Krishna Dronamraju's work in preserving the legacy of Haldane, a multifaceted geneticist. It also discusses the book "Evolutionary Genetics and Environmental Stress" by A. A. Hoffman and P.A. Parsons, which explores how various organisms adapt to extreme environmental stresses. The book is valuable for its insights into how other species cope with stress, which could inform our understanding of human homeostasis and multifactorial diseases. The review emphasizes the need for a more detailed genetic understanding of human homeostasis and the role of individual variations in disease prevention. It suggests that the human genome initiative could provide crucial data for this understanding, particularly in the context of homeostatic systems that protect against disease-causing stresses. The review concludes by advocating for a broader perspective on disease, viewing it as a result of the incongruence between human biology and the environment, and highlighting the potential of the human genome project to advance this understanding.The review highlights the importance of Krishna Dronamraju's work in preserving the legacy of Haldane, a multifaceted geneticist. It also discusses the book "Evolutionary Genetics and Environmental Stress" by A. A. Hoffman and P.A. Parsons, which explores how various organisms adapt to extreme environmental stresses. The book is valuable for its insights into how other species cope with stress, which could inform our understanding of human homeostasis and multifactorial diseases. The review emphasizes the need for a more detailed genetic understanding of human homeostasis and the role of individual variations in disease prevention. It suggests that the human genome initiative could provide crucial data for this understanding, particularly in the context of homeostatic systems that protect against disease-causing stresses. The review concludes by advocating for a broader perspective on disease, viewing it as a result of the incongruence between human biology and the environment, and highlighting the potential of the human genome project to advance this understanding.