The article "Evolving Strategies and Materials for Scaffold Development in Regenerative Dentistry" provides a comprehensive overview of the advancements in scaffold technology and materials used in regenerative dentistry. The authors highlight the interdisciplinary nature of stem cell applications and scaffold design, emphasizing their role in tissue engineering and regenerative therapy. Scaffolds, which serve as temporary frameworks for cell adhesion, proliferation, and differentiation, have evolved significantly over the past three decades. The review covers the historical background of regenerative medicine, the timeline of significant advancements in scaffold development, and the current state of the art in scaffold approaches. Key advancements include the introduction of synthetic polymers like polylactic acid (PLA) and polyglycolic acid (PGA), the development of hybrid scaffolds combining natural and synthetic materials, and the advent of 3D bioprinting, which allows for precise control over scaffold geometry and material composition. The article also discusses the use of advanced materials such as composites, hydrogels, and bioactive materials, which enhance cell proliferation, viability, and osteogenic activity. The review further explores the application of mesenchymal stem cells (MSCs) in regenerative dentistry, highlighting their importance in tissue regeneration. It examines various sources of MSCs, including bone marrow, dental pulp, and adipose tissue, and their interactions with different scaffold materials. Additionally, the article delves into the use of 3D bioprinting for creating patient-specific scaffolds and the potential of whole tooth regeneration, a promising area that could revolutionize tooth replacement methods. The authors conclude by identifying future directions, emphasizing the need for biomimetic approaches, clinical translation, in-depth material investigations, and standardization in the field of regenerative dentistry. The review is based on a comprehensive literature search and the analysis of influential publications, leveraging large language models (LLMs) like Bard and ChatGPT to identify the most commonly used materials and trends in scaffold development.The article "Evolving Strategies and Materials for Scaffold Development in Regenerative Dentistry" provides a comprehensive overview of the advancements in scaffold technology and materials used in regenerative dentistry. The authors highlight the interdisciplinary nature of stem cell applications and scaffold design, emphasizing their role in tissue engineering and regenerative therapy. Scaffolds, which serve as temporary frameworks for cell adhesion, proliferation, and differentiation, have evolved significantly over the past three decades. The review covers the historical background of regenerative medicine, the timeline of significant advancements in scaffold development, and the current state of the art in scaffold approaches. Key advancements include the introduction of synthetic polymers like polylactic acid (PLA) and polyglycolic acid (PGA), the development of hybrid scaffolds combining natural and synthetic materials, and the advent of 3D bioprinting, which allows for precise control over scaffold geometry and material composition. The article also discusses the use of advanced materials such as composites, hydrogels, and bioactive materials, which enhance cell proliferation, viability, and osteogenic activity. The review further explores the application of mesenchymal stem cells (MSCs) in regenerative dentistry, highlighting their importance in tissue regeneration. It examines various sources of MSCs, including bone marrow, dental pulp, and adipose tissue, and their interactions with different scaffold materials. Additionally, the article delves into the use of 3D bioprinting for creating patient-specific scaffolds and the potential of whole tooth regeneration, a promising area that could revolutionize tooth replacement methods. The authors conclude by identifying future directions, emphasizing the need for biomimetic approaches, clinical translation, in-depth material investigations, and standardization in the field of regenerative dentistry. The review is based on a comprehensive literature search and the analysis of influential publications, leveraging large language models (LLMs) like Bard and ChatGPT to identify the most commonly used materials and trends in scaffold development.