This review discusses the evolution of scaffold strategies and materials in regenerative dentistry. Scaffolds are essential for tissue regeneration and restoring damaged dental structures. They provide a framework for cells to adhere, proliferate, and differentiate into functional tissues. The review analyzes the most commonly used materials for scaffold fabrication over the last 10 years using a novel AI-based approach. It also explores bioprinting, stem cell colonization, and the potential for whole tooth regeneration. The review highlights recent advancements in scaffold development, particularly with the advent of 3D bioprinting technologies. It emphasizes the importance of optimizing scaffold design and personalization through precise 3D bioprinting. The review also discusses the role of mesenchymal stem cells, various biomaterials, and the potential of 4D materials in scaffold development. The study identifies key trends and future directions in scaffold approaches, including the use of decellularized matrices, hydrogels, and bioactive materials. The review concludes that multi-material scaffolds, bioprinting, and a focus on stem cell interaction are crucial for successful regenerative dentistry. Future research should emphasize biomimetic principles, clinical translation, and in-depth material investigations to advance scaffold technologies in regenerative dentistry.This review discusses the evolution of scaffold strategies and materials in regenerative dentistry. Scaffolds are essential for tissue regeneration and restoring damaged dental structures. They provide a framework for cells to adhere, proliferate, and differentiate into functional tissues. The review analyzes the most commonly used materials for scaffold fabrication over the last 10 years using a novel AI-based approach. It also explores bioprinting, stem cell colonization, and the potential for whole tooth regeneration. The review highlights recent advancements in scaffold development, particularly with the advent of 3D bioprinting technologies. It emphasizes the importance of optimizing scaffold design and personalization through precise 3D bioprinting. The review also discusses the role of mesenchymal stem cells, various biomaterials, and the potential of 4D materials in scaffold development. The study identifies key trends and future directions in scaffold approaches, including the use of decellularized matrices, hydrogels, and bioactive materials. The review concludes that multi-material scaffolds, bioprinting, and a focus on stem cell interaction are crucial for successful regenerative dentistry. Future research should emphasize biomimetic principles, clinical translation, and in-depth material investigations to advance scaffold technologies in regenerative dentistry.