This article discusses the effectiveness of exercise in managing osteoarthritis (OA) of the knee, focusing on a 55-year-old man named Mr. S who has moderate OA in both knees. The Cochrane review highlights that exercise can help reduce pain and improve physical function in patients with knee OA. Mr. S, who had a sedentary lifestyle and increased weight, started an exercise program that included quadriceps and gluteal muscle strengthening, calf and hamstring stretches, and progressive walking and cycling exercises. After 8 weeks, he reported significant improvements in pain and physical function, exceeding the minimal clinically important difference on both the visual analog scale and the Patient-Specific Functional Scale. The article emphasizes that exercise is a recommended first-line treatment for OA and can be tailored to individual needs, with variations in delivery, content, and dosage not affecting outcomes. Physical therapists play a crucial role in prescribing appropriate exercises to manage OA effectively.This article discusses the effectiveness of exercise in managing osteoarthritis (OA) of the knee, focusing on a 55-year-old man named Mr. S who has moderate OA in both knees. The Cochrane review highlights that exercise can help reduce pain and improve physical function in patients with knee OA. Mr. S, who had a sedentary lifestyle and increased weight, started an exercise program that included quadriceps and gluteal muscle strengthening, calf and hamstring stretches, and progressive walking and cycling exercises. After 8 weeks, he reported significant improvements in pain and physical function, exceeding the minimal clinically important difference on both the visual analog scale and the Patient-Specific Functional Scale. The article emphasizes that exercise is a recommended first-line treatment for OA and can be tailored to individual needs, with variations in delivery, content, and dosage not affecting outcomes. Physical therapists play a crucial role in prescribing appropriate exercises to manage OA effectively.