This review, published in *The Cochrane Database of Systematic Reviews*, evaluates the effectiveness of exercise as a means of achieving weight loss in adults with overweight or obesity. The study includes 43 randomized controlled trials involving 3476 participants. Key findings include: 1. **Weight Loss**: Exercise alone resulted in small weight losses, but when combined with diet, it led to greater weight reduction (WMD -1.1 kg; 95% CI -1.5 to -0.6). High-intensity exercise was associated with a greater weight loss compared to low-intensity exercise (WMD -1.5 kg; 95% CI -2.3 to -0.7). 2. **Cardiovascular Outcomes**: Exercise interventions improved cardiovascular disease (CVD) risk factors such as systolic and diastolic blood pressure, serum cholesterol, triglycerides, and fasting glucose levels. High-intensity exercise had a more significant impact on reducing fasting serum glucose compared to low-intensity exercise. 3. **Subgroup Analysis**: The effect of exercise on weight loss was not significantly influenced by sex or age. However, the study found that younger participants (mean age < 45 years) had a greater weight loss compared to older participants (mean age > 45 years). 4. **Sensitivity Analysis**: The review did not identify any adverse events, quality of life, morbidity, costs, or mortality data. The authors conclude that exercise is a valuable tool for weight loss, particularly when combined with dietary changes. Exercise also has positive effects on CVD risk factors, even if no significant weight loss is achieved.This review, published in *The Cochrane Database of Systematic Reviews*, evaluates the effectiveness of exercise as a means of achieving weight loss in adults with overweight or obesity. The study includes 43 randomized controlled trials involving 3476 participants. Key findings include: 1. **Weight Loss**: Exercise alone resulted in small weight losses, but when combined with diet, it led to greater weight reduction (WMD -1.1 kg; 95% CI -1.5 to -0.6). High-intensity exercise was associated with a greater weight loss compared to low-intensity exercise (WMD -1.5 kg; 95% CI -2.3 to -0.7). 2. **Cardiovascular Outcomes**: Exercise interventions improved cardiovascular disease (CVD) risk factors such as systolic and diastolic blood pressure, serum cholesterol, triglycerides, and fasting glucose levels. High-intensity exercise had a more significant impact on reducing fasting serum glucose compared to low-intensity exercise. 3. **Subgroup Analysis**: The effect of exercise on weight loss was not significantly influenced by sex or age. However, the study found that younger participants (mean age < 45 years) had a greater weight loss compared to older participants (mean age > 45 years). 4. **Sensitivity Analysis**: The review did not identify any adverse events, quality of life, morbidity, costs, or mortality data. The authors conclude that exercise is a valuable tool for weight loss, particularly when combined with dietary changes. Exercise also has positive effects on CVD risk factors, even if no significant weight loss is achieved.