2019, Issue 1 | Sherrington C, Fairhall NJ, Wallbank GK, Tiedemann A, Michaleff ZA, Howard K, Clemson L, Hopewell S, Lamb SE
This review by Sherrington et al. (2019) assesses the effects of exercise interventions on preventing falls in older people living in the community. The review includes 108 randomized controlled trials (RCTs) with 23,407 participants from 25 countries, with an average age of 76 years and a 77% female participation rate. Most trials had unclear or high risk of bias, primarily due to lack of blinding.
The primary outcome, the rate of falls, showed that exercise interventions reduced the rate of falls by 23% (rate ratio [RR] 0.77, 95% confidence interval [CI] 0.71 to 0.83; 59 studies; high-certainty evidence). This equates to an average of 195 fewer falls per 1000 people followed over one year. Exercise also reduced the number of people experiencing one or more falls by 15% (RR 0.85, 95% CI 0.81 to 0.89; 63 studies; high-certainty evidence).
Subgroup analyses showed no significant differences in the effect of exercise on falls outcomes based on baseline fall risk or age (75 years and above). Other outcomes, such as the number of people experiencing fall-related fractures, falls requiring medical attention, and hospital admissions, were less certain due to the low number of studies and participants. Exercise may reduce the number of people experiencing fall-related fractures by 27% (RR 0.73, 95% CI 0.56 to 0.95; 10 studies; low-certainty evidence) and the number of people experiencing falls requiring medical attention by 39% (RR 0.61, 95% CI 0.47 to 0.79; 5 studies; low-certainty evidence). The effect on hospital admissions was unclear (RR 0.78, 95% CI 0.51 to 1.18; 2 studies; very low-certainty evidence).
Health-related quality of life was minimally affected by exercise, with a small but not statistically significant reduction in the standardized mean difference (SMD) of -0.03 (95% CI -0.10 to 0.04; 15 studies; low-certainty evidence).
Adverse events were reported in 27 trials (6019 participants), but were mostly non-serious musculoskeletal events. Fourteen trials reported no adverse events, and two serious adverse events (one pelvic stress fracture and one inguinal hernia surgery) were reported in one trial.
Different types of exercise had varying impacts on falls. Balance and functional exercises reduced the rate of falls by 24% (RRThis review by Sherrington et al. (2019) assesses the effects of exercise interventions on preventing falls in older people living in the community. The review includes 108 randomized controlled trials (RCTs) with 23,407 participants from 25 countries, with an average age of 76 years and a 77% female participation rate. Most trials had unclear or high risk of bias, primarily due to lack of blinding.
The primary outcome, the rate of falls, showed that exercise interventions reduced the rate of falls by 23% (rate ratio [RR] 0.77, 95% confidence interval [CI] 0.71 to 0.83; 59 studies; high-certainty evidence). This equates to an average of 195 fewer falls per 1000 people followed over one year. Exercise also reduced the number of people experiencing one or more falls by 15% (RR 0.85, 95% CI 0.81 to 0.89; 63 studies; high-certainty evidence).
Subgroup analyses showed no significant differences in the effect of exercise on falls outcomes based on baseline fall risk or age (75 years and above). Other outcomes, such as the number of people experiencing fall-related fractures, falls requiring medical attention, and hospital admissions, were less certain due to the low number of studies and participants. Exercise may reduce the number of people experiencing fall-related fractures by 27% (RR 0.73, 95% CI 0.56 to 0.95; 10 studies; low-certainty evidence) and the number of people experiencing falls requiring medical attention by 39% (RR 0.61, 95% CI 0.47 to 0.79; 5 studies; low-certainty evidence). The effect on hospital admissions was unclear (RR 0.78, 95% CI 0.51 to 1.18; 2 studies; very low-certainty evidence).
Health-related quality of life was minimally affected by exercise, with a small but not statistically significant reduction in the standardized mean difference (SMD) of -0.03 (95% CI -0.10 to 0.04; 15 studies; low-certainty evidence).
Adverse events were reported in 27 trials (6019 participants), but were mostly non-serious musculoskeletal events. Fourteen trials reported no adverse events, and two serious adverse events (one pelvic stress fracture and one inguinal hernia surgery) were reported in one trial.
Different types of exercise had varying impacts on falls. Balance and functional exercises reduced the rate of falls by 24% (RR