ExoCarta is a manually curated, web-based compendium that catalogs exosomal proteins, RNAs, and lipids. Since its inception, the database has been highly accessed, with over 54,000 visitors from 135 countries. The current version of ExoCarta includes 41,860 proteins, 77,540 RNAs, and 1,116 lipid molecules from more than 286 exosomal studies, all annotated with ISEV minimal experimental requirements. Key features of ExoCarta include dynamic protein-protein interaction networks, biological pathways, and the ability to download exosomal datasets for further analysis using tools like FunRich. The database also allows users to search for exosomal proteins based on content types, species, tissue/cell types, and gene symbols. ExoCarta serves as a valuable resource for researchers studying exosomal biogenesis, sorting, and secretion under normal and disease conditions.ExoCarta is a manually curated, web-based compendium that catalogs exosomal proteins, RNAs, and lipids. Since its inception, the database has been highly accessed, with over 54,000 visitors from 135 countries. The current version of ExoCarta includes 41,860 proteins, 77,540 RNAs, and 1,116 lipid molecules from more than 286 exosomal studies, all annotated with ISEV minimal experimental requirements. Key features of ExoCarta include dynamic protein-protein interaction networks, biological pathways, and the ability to download exosomal datasets for further analysis using tools like FunRich. The database also allows users to search for exosomal proteins based on content types, species, tissue/cell types, and gene symbols. ExoCarta serves as a valuable resource for researchers studying exosomal biogenesis, sorting, and secretion under normal and disease conditions.