ExoCarta is a manually curated, web-based database that compiles exosomal proteins, RNAs, and lipids from over 286 studies. It was first published in 2009 and has since been accessed by over 54,000 users from 135 countries. The database includes 41,860 proteins, >7,540 RNAs, and 1,116 lipids from 10 species. ExoCarta features dynamic protein-protein interaction networks and biological pathways of exosomal proteins. Users can download datasets and use them in FunRich for further analysis. The database also includes annotations according to the International Society for Extracellular Vesicles (ISEV) standards, ensuring quality and consistency. ExoCarta allows community contributions and provides credits for users. It serves as a resource for identifying exosomal markers and oncogenic proteins, with many of the top 20 most frequently identified exosomal proteins known to be mutated in various cancers. The database is freely accessible and supports research into exosome biogenesis, sorting, and secretion. ExoCarta is a valuable tool for researchers studying exosomes and their role in intercellular communication and disease.ExoCarta is a manually curated, web-based database that compiles exosomal proteins, RNAs, and lipids from over 286 studies. It was first published in 2009 and has since been accessed by over 54,000 users from 135 countries. The database includes 41,860 proteins, >7,540 RNAs, and 1,116 lipids from 10 species. ExoCarta features dynamic protein-protein interaction networks and biological pathways of exosomal proteins. Users can download datasets and use them in FunRich for further analysis. The database also includes annotations according to the International Society for Extracellular Vesicles (ISEV) standards, ensuring quality and consistency. ExoCarta allows community contributions and provides credits for users. It serves as a resource for identifying exosomal markers and oncogenic proteins, with many of the top 20 most frequently identified exosomal proteins known to be mutated in various cancers. The database is freely accessible and supports research into exosome biogenesis, sorting, and secretion. ExoCarta is a valuable tool for researchers studying exosomes and their role in intercellular communication and disease.