This study investigates the endocrine functions of the anterior pituitary in patients with long COVID, aiming to identify potential deficiencies that may explain the persistence of symptoms. A cross-sectional study was conducted on 64 adult patients previously infected with SARS-CoV-2, divided into two groups: fully recovered patients (Group 1) and those experiencing long COVID (Group 2). The primary outcome was the comparison of corticotroph and somatotroph functions. Results showed that Group 2 had a significantly higher frequency of anterior pituitary deficits compared to Group 1, with more patients exhibiting corticotroph and somatotroph deficiencies. Baseline cortisol levels were significantly lower in Group 2, and the peak cortisol level was also lower. Insulin-like growth factor-1 (IGF-1) levels were comparable between the groups, but the peak growth hormone (GH) level was significantly lower in Group 2. The study concludes that long COVID patients are more likely to have anterior pituitary deficiencies, supporting the endocrine hypothesis in explaining long COVID. Further research is needed to confirm this link and improve the management of post-COVID-19 syndrome.This study investigates the endocrine functions of the anterior pituitary in patients with long COVID, aiming to identify potential deficiencies that may explain the persistence of symptoms. A cross-sectional study was conducted on 64 adult patients previously infected with SARS-CoV-2, divided into two groups: fully recovered patients (Group 1) and those experiencing long COVID (Group 2). The primary outcome was the comparison of corticotroph and somatotroph functions. Results showed that Group 2 had a significantly higher frequency of anterior pituitary deficits compared to Group 1, with more patients exhibiting corticotroph and somatotroph deficiencies. Baseline cortisol levels were significantly lower in Group 2, and the peak cortisol level was also lower. Insulin-like growth factor-1 (IGF-1) levels were comparable between the groups, but the peak growth hormone (GH) level was significantly lower in Group 2. The study concludes that long COVID patients are more likely to have anterior pituitary deficiencies, supporting the endocrine hypothesis in explaining long COVID. Further research is needed to confirm this link and improve the management of post-COVID-19 syndrome.