Apigenin, a flavonoid found in various plants and foods, has shown potential as an anti-inflammatory and neuroprotective agent in various neurological conditions, including neurodegenerative diseases, cancer, and cardiovascular diseases. This review explores the role of apigenin in neuroinflammation, highlighting its therapeutic potential and mechanisms of action. Apigenin is present in vegetables, fruits, herbs, and beverages, and has been studied for its effects on neuroinflammation, oxidative stress, and neurodegenerative diseases such as Alzheimer's, Parkinson's, and multiple sclerosis. Apigenin exhibits anti-inflammatory properties by modulating cytokine production, reducing oxidative stress, and inhibiting the activation of microglia and astrocytes. It also plays a role in neuroprotection by reducing neuronal death and promoting neurogenesis. In cancer, apigenin has been shown to inhibit angiogenesis and tumor growth by reducing the expression of pro-inflammatory markers and inhibiting the activity of matrix metalloproteinases. In cardiovascular diseases, apigenin has been shown to reduce oxidative stress and inflammation, and improve outcomes in stroke models. Overall, apigenin shows promise as a therapeutic agent for neuroinflammation and related diseases, and further research is needed to fully understand its clinical applications.Apigenin, a flavonoid found in various plants and foods, has shown potential as an anti-inflammatory and neuroprotective agent in various neurological conditions, including neurodegenerative diseases, cancer, and cardiovascular diseases. This review explores the role of apigenin in neuroinflammation, highlighting its therapeutic potential and mechanisms of action. Apigenin is present in vegetables, fruits, herbs, and beverages, and has been studied for its effects on neuroinflammation, oxidative stress, and neurodegenerative diseases such as Alzheimer's, Parkinson's, and multiple sclerosis. Apigenin exhibits anti-inflammatory properties by modulating cytokine production, reducing oxidative stress, and inhibiting the activation of microglia and astrocytes. It also plays a role in neuroprotection by reducing neuronal death and promoting neurogenesis. In cancer, apigenin has been shown to inhibit angiogenesis and tumor growth by reducing the expression of pro-inflammatory markers and inhibiting the activity of matrix metalloproteinases. In cardiovascular diseases, apigenin has been shown to reduce oxidative stress and inflammation, and improve outcomes in stroke models. Overall, apigenin shows promise as a therapeutic agent for neuroinflammation and related diseases, and further research is needed to fully understand its clinical applications.