This review explores the potential of apigenin, a natural flavonoid found in various plants, as an anti-inflammatory agent in the context of neuroinflammation. Neuroinflammation, characterized by oxidative stress and neuronal or oligodendrocyte cell death, is a hallmark of several central nervous system disorders. Apigenin has been studied for its multifaceted effects and underlying mechanisms in neuroinflammation across diverse neurological conditions, including multiple sclerosis, Parkinson's disease, Alzheimer's disease, cancer, cardiovascular diseases, cognitive and memory disorders, and toxicity related to trace metals and other chemicals. The review highlights the therapeutic promise of apigenin and calls for further investigation into its clinical applications. Key mechanisms include modulation of inflammatory cytokines, suppression of pro-inflammatory enzymes, and promotion of neuroprotective factors. Apigenin's ability to reduce immune cell infiltration, modulate signaling pathways, and improve cognitive function makes it a promising nutraceutical for managing neuroinflammation.This review explores the potential of apigenin, a natural flavonoid found in various plants, as an anti-inflammatory agent in the context of neuroinflammation. Neuroinflammation, characterized by oxidative stress and neuronal or oligodendrocyte cell death, is a hallmark of several central nervous system disorders. Apigenin has been studied for its multifaceted effects and underlying mechanisms in neuroinflammation across diverse neurological conditions, including multiple sclerosis, Parkinson's disease, Alzheimer's disease, cancer, cardiovascular diseases, cognitive and memory disorders, and toxicity related to trace metals and other chemicals. The review highlights the therapeutic promise of apigenin and calls for further investigation into its clinical applications. Key mechanisms include modulation of inflammatory cytokines, suppression of pro-inflammatory enzymes, and promotion of neuroprotective factors. Apigenin's ability to reduce immune cell infiltration, modulate signaling pathways, and improve cognitive function makes it a promising nutraceutical for managing neuroinflammation.