This study investigates the translation of circular RNAs (circRNAs) in human cells, focusing on the role of N6-methyladenosine (m6A) modification. The authors found that m6A motifs are enriched in circRNAs and a single m6A site is sufficient to drive translation initiation. This process requires the initiation factor eIF4G2 and the m6A reader YTHDF3, and is enhanced by methyltransferases METTL3/14 and inhibited by demethylase FTO. The study also reveals that m6A-driven translation of circRNAs is widespread, with hundreds of endogenous circRNAs having translation potential. Further analyses using polysome profiling, computational prediction, and mass spectrometry confirmed the presence of translatable circRNAs and their coding potential. The findings suggest that circRNA-derived proteins may play a role in cellular responses to environmental stress, challenging the traditional view of circRNAs as non-coding RNAs.This study investigates the translation of circular RNAs (circRNAs) in human cells, focusing on the role of N6-methyladenosine (m6A) modification. The authors found that m6A motifs are enriched in circRNAs and a single m6A site is sufficient to drive translation initiation. This process requires the initiation factor eIF4G2 and the m6A reader YTHDF3, and is enhanced by methyltransferases METTL3/14 and inhibited by demethylase FTO. The study also reveals that m6A-driven translation of circRNAs is widespread, with hundreds of endogenous circRNAs having translation potential. Further analyses using polysome profiling, computational prediction, and mass spectrometry confirmed the presence of translatable circRNAs and their coding potential. The findings suggest that circRNA-derived proteins may play a role in cellular responses to environmental stress, challenging the traditional view of circRNAs as non-coding RNAs.