The article "Extracellular-matrix tethering regulates stem-cell fate" by Britta Trappmann et al., published in *Nature Materials* in 2012, explores the role of extracellular matrix (ECM) tethering in regulating stem cell fate. The study investigates how the physical interactions between ECM and stem cells influence the differentiation and behavior of these cells. The authors used advanced microscopy techniques to observe and analyze these interactions, providing insights into the mechanisms underlying stem cell fate determination.The article "Extracellular-matrix tethering regulates stem-cell fate" by Britta Trappmann et al., published in *Nature Materials* in 2012, explores the role of extracellular matrix (ECM) tethering in regulating stem cell fate. The study investigates how the physical interactions between ECM and stem cells influence the differentiation and behavior of these cells. The authors used advanced microscopy techniques to observe and analyze these interactions, providing insights into the mechanisms underlying stem cell fate determination.