The article "Extracellular Matrix Components and Mechanosensing Pathways in Health and Disease" by Aikaterini Berdiaki, Monica Neagu, Petros Tzanakakis, Ioanna Spyridaki, Serge Pérez, and Dragana Nikitovic provides a comprehensive overview of the roles of glycosaminoglycans (GAGs) and proteoglycans (PGs) in mechanosensing pathways. GAGs, such as heparan sulfate (HS) and chondroitin sulfate (CS), interact with cell surface receptors like integrins and receptor tyrosine kinases to modulate cellular responses to mechanical stimuli. PGs, which consist of a core protein covalently linked to GAG chains, play a crucial role in regulating tissue mechanics and cell behavior, maintaining tissue homeostasis. Dysregulation of these pathways is implicated in various pathological conditions, including cancer and inflammation. The article highlights the importance of understanding the mechanisms by which GAGs and PGs modulate cellular responses to mechanical forces, emphasizing their potential as therapeutic targets for mitigating mechano-driven pathologies. Key topics covered include the interplay between the extracellular matrix (ECM) and the cellular glycocalyx (GCX), the mechanical properties of the ECM, receptors involved in mechanotransduction, and the mechanisms of mechanosensing. The review also discusses the role of GAGs and PGs in mechanotransduction, including their interactions with integrins and cadherins, and their impact on cell-ECM interactions.The article "Extracellular Matrix Components and Mechanosensing Pathways in Health and Disease" by Aikaterini Berdiaki, Monica Neagu, Petros Tzanakakis, Ioanna Spyridaki, Serge Pérez, and Dragana Nikitovic provides a comprehensive overview of the roles of glycosaminoglycans (GAGs) and proteoglycans (PGs) in mechanosensing pathways. GAGs, such as heparan sulfate (HS) and chondroitin sulfate (CS), interact with cell surface receptors like integrins and receptor tyrosine kinases to modulate cellular responses to mechanical stimuli. PGs, which consist of a core protein covalently linked to GAG chains, play a crucial role in regulating tissue mechanics and cell behavior, maintaining tissue homeostasis. Dysregulation of these pathways is implicated in various pathological conditions, including cancer and inflammation. The article highlights the importance of understanding the mechanisms by which GAGs and PGs modulate cellular responses to mechanical forces, emphasizing their potential as therapeutic targets for mitigating mechano-driven pathologies. Key topics covered include the interplay between the extracellular matrix (ECM) and the cellular glycocalyx (GCX), the mechanical properties of the ECM, receptors involved in mechanotransduction, and the mechanisms of mechanosensing. The review also discusses the role of GAGs and PGs in mechanotransduction, including their interactions with integrins and cadherins, and their impact on cell-ECM interactions.