The article discusses the role of extracellular vesicles (EVs) in cancer and their potential implications for cancer care. EVs, including exosomes and shed microvesicles (sMVs), play a crucial role in cell-to-cell communication and contribute to cancer development, invasion, and metastasis. These particles carry various molecules such as oncoproteins, peptides, RNA species, lipids, and DNA fragments, which can influence recipient cells to undergo phenotypic changes. The biophysical properties and physiological functions of EVs are explored, highlighting their potential as biomarkers for diagnosis, prognosis, and surveillance of cancer. The article also reviews the biogenesis of exosomes and sMVs, their cargo profiles, and the mechanisms by which they affect recipient cells. Additionally, it discusses the clinical utility of EVs, particularly in liquid biopsies, and the challenges in standardizing methods for isolation, quantification, and analysis of EVs from complex biological samples. The authors emphasize the need for further research to optimize EV-based diagnostics and therapeutics, including the development of stereospecific antibodies and the understanding of EV half-lives in biological samples.The article discusses the role of extracellular vesicles (EVs) in cancer and their potential implications for cancer care. EVs, including exosomes and shed microvesicles (sMVs), play a crucial role in cell-to-cell communication and contribute to cancer development, invasion, and metastasis. These particles carry various molecules such as oncoproteins, peptides, RNA species, lipids, and DNA fragments, which can influence recipient cells to undergo phenotypic changes. The biophysical properties and physiological functions of EVs are explored, highlighting their potential as biomarkers for diagnosis, prognosis, and surveillance of cancer. The article also reviews the biogenesis of exosomes and sMVs, their cargo profiles, and the mechanisms by which they affect recipient cells. Additionally, it discusses the clinical utility of EVs, particularly in liquid biopsies, and the challenges in standardizing methods for isolation, quantification, and analysis of EVs from complex biological samples. The authors emphasize the need for further research to optimize EV-based diagnostics and therapeutics, including the development of stereospecific antibodies and the understanding of EV half-lives in biological samples.