A case-control study of 841 patients with pancreatic adenocarcinoma and 754 healthy controls found that being overweight or obese during early adulthood was associated with an increased risk of pancreatic cancer, younger age of onset, and reduced overall survival. The study showed that individuals who were overweight (BMI 25-29.9) or obese (BMI ≥30) during their 20s had a higher risk of pancreatic cancer compared to those with normal weight. The association was stronger in men and ever-smokers than in women and never-smokers. Overweight or obese individuals from ages 20 to 49 had an earlier onset of pancreatic cancer, with a median age of onset of 64 years for normal weight patients, 61 years for overweight patients, and 59 years for obese patients. Obesity at an older age was associated with reduced overall survival, regardless of disease stage or tumor resection status. The population-attributable risk of pancreatic cancer due to being overweight or obese was 10.3% for never smokers and 21.3% for ever smokers. The study also found that higher BMI in early adulthood was associated with increased risk of pancreatic cancer, with the strongest association seen in individuals who were overweight or obese from ages 30 to 39. The study highlights the importance of body weight in the development and progression of pancreatic cancer, suggesting that weight control in young adults could be a key strategy for prevention. The findings support the role of excess body weight in pancreatic cancer risk and emphasize the need for further research into the mechanisms linking obesity to cancer.A case-control study of 841 patients with pancreatic adenocarcinoma and 754 healthy controls found that being overweight or obese during early adulthood was associated with an increased risk of pancreatic cancer, younger age of onset, and reduced overall survival. The study showed that individuals who were overweight (BMI 25-29.9) or obese (BMI ≥30) during their 20s had a higher risk of pancreatic cancer compared to those with normal weight. The association was stronger in men and ever-smokers than in women and never-smokers. Overweight or obese individuals from ages 20 to 49 had an earlier onset of pancreatic cancer, with a median age of onset of 64 years for normal weight patients, 61 years for overweight patients, and 59 years for obese patients. Obesity at an older age was associated with reduced overall survival, regardless of disease stage or tumor resection status. The population-attributable risk of pancreatic cancer due to being overweight or obese was 10.3% for never smokers and 21.3% for ever smokers. The study also found that higher BMI in early adulthood was associated with increased risk of pancreatic cancer, with the strongest association seen in individuals who were overweight or obese from ages 30 to 39. The study highlights the importance of body weight in the development and progression of pancreatic cancer, suggesting that weight control in young adults could be a key strategy for prevention. The findings support the role of excess body weight in pancreatic cancer risk and emphasize the need for further research into the mechanisms linking obesity to cancer.