Facilitating the development of urgently required combination vaccines

Facilitating the development of urgently required combination vaccines

2024 | Hausdorff WP, Madhi SA, Kang G, Kaboré L, Tufet Bayona M, Giersing BK
this appendix is part of the original submission and has been peer reviewed. it is posted as supplied by the authors. supplement to: hausdorff wp, madhi sa, kang g, kabore l, tufet bayona m, giersing bk. facilitating the development of urgently required combination vaccines. lancet glob health 2024; published online april 15. https://doi.org/10.1016/s2214-109x(24)00092-5. the article discusses the development of combination vaccines to address urgent public health needs. figure 1 shows the increasing number of pathogens and diseases preventable by vaccination, with different age groups highlighted. the twelve pathogens in bold represent globally recommended vaccines, while those in plain font are for high-burden contexts. the 2030 additions are not yet formally recommended. vaccines are grouped by age ranges. figure 2 shows the evolution of vaccines recommended by who, with multi-pathogen combination vaccines indicated by boxes touching each other. solid boxes represent globally recommended vaccines, while hashed boxes are for high-risk or regional populations. all vaccines are administered parenterally except for rotavirus and certain polio, cholera, and influenza vaccines. the 2030 column shows vaccines hypothesized to be recommended in addition to those already recommended in 2023. a table provides illustrative examples of syndromic combination vaccines. rsv = respiratory syncytial virus.this appendix is part of the original submission and has been peer reviewed. it is posted as supplied by the authors. supplement to: hausdorff wp, madhi sa, kang g, kabore l, tufet bayona m, giersing bk. facilitating the development of urgently required combination vaccines. lancet glob health 2024; published online april 15. https://doi.org/10.1016/s2214-109x(24)00092-5. the article discusses the development of combination vaccines to address urgent public health needs. figure 1 shows the increasing number of pathogens and diseases preventable by vaccination, with different age groups highlighted. the twelve pathogens in bold represent globally recommended vaccines, while those in plain font are for high-burden contexts. the 2030 additions are not yet formally recommended. vaccines are grouped by age ranges. figure 2 shows the evolution of vaccines recommended by who, with multi-pathogen combination vaccines indicated by boxes touching each other. solid boxes represent globally recommended vaccines, while hashed boxes are for high-risk or regional populations. all vaccines are administered parenterally except for rotavirus and certain polio, cholera, and influenza vaccines. the 2030 column shows vaccines hypothesized to be recommended in addition to those already recommended in 2023. a table provides illustrative examples of syndromic combination vaccines. rsv = respiratory syncytial virus.
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