The article provides an overview of the facilitative glucose transporters (GLUTs), a family of proteins that mediate glucose transport across cell membranes. Six members of the GLUT family have been identified, each with distinct kinetic and regulatory properties. Glut1 is widely expressed and plays a crucial role in providing basal glucose requirements for many cells, especially in epithelial and endothelial barrier tissues. Glut2, a high-Km isoform, is expressed in hepatocytes, pancreatic β cells, and intestinal and renal epithelial cells, facilitating high-capacity glucose transport. Glut3 is responsible for glucose uptake into neurons, while Glut4 is specifically expressed in insulin-sensitive tissues like fat and muscle, regulating glucose disposal postprandially. Glut5 is a fructose transporter abundant in spermatozoa and intestinal cells, and Glut7 is involved in the export of glucose from the endoplasmic reticulum. The article also discusses the structure, function, and regulation of these transporters, highlighting their importance in maintaining glucose homeostasis in various tissues.The article provides an overview of the facilitative glucose transporters (GLUTs), a family of proteins that mediate glucose transport across cell membranes. Six members of the GLUT family have been identified, each with distinct kinetic and regulatory properties. Glut1 is widely expressed and plays a crucial role in providing basal glucose requirements for many cells, especially in epithelial and endothelial barrier tissues. Glut2, a high-Km isoform, is expressed in hepatocytes, pancreatic β cells, and intestinal and renal epithelial cells, facilitating high-capacity glucose transport. Glut3 is responsible for glucose uptake into neurons, while Glut4 is specifically expressed in insulin-sensitive tissues like fat and muscle, regulating glucose disposal postprandially. Glut5 is a fructose transporter abundant in spermatozoa and intestinal cells, and Glut7 is involved in the export of glucose from the endoplasmic reticulum. The article also discusses the structure, function, and regulation of these transporters, highlighting their importance in maintaining glucose homeostasis in various tissues.